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Observational Study
. 2022 May 13;22(1):238.
doi: 10.1186/s12876-022-02309-7.

Relationship between HER2 overexpression and long-term outcomes of early gastric cancer: a prospective observational study with a 6-year follow-up

Hui Li #  1   2 , Longsong Li #  1 , Nan Zhang  1 , Zixin Wang  1 , Ning Xu  1 , Enqiang Linghu  3 , Ningli Chai  4
Affiliations
Observational Study

Relationship between HER2 overexpression and long-term outcomes of early gastric cancer: a prospective observational study with a 6-year follow-up

Hui Li et al. BMC Gastroenterol. .

Abstract

Background: Studies have confirmed the prognostic value of the expression status of human epidermal growth factor receptor 2 (HER2) in advanced gastric cancer. However, its role in early gastric cancer (EGC) remains largely unknown. This study explored the association between HER2 overexpression and clinical outcomes of patients with EGC.

Methods: A total of 211 patients who had undergone endoscopic treatment for pN0 EGC were enrolled. The HER2 expression status was assessed using immunohistochemistry (IHC).

Results: The prevalence of HER2 overexpression was 14.2%. HER2 overexpression showed a significant correlation with tumor location (P = 0.033). Multivariate analysis showed that HER2 overexpression was significantly associated with an increased risk of tumor recurrence in pN0 EGC (hazard ratio [HR] = 3.97; 95% confidence interval [CI] 1.30-12.14; P = 0.016) but not overall survival (OS) or disease-specific survival (DSS). Of the included patients, age was associated with OS (HR = 1.11; 95% CI 1.04-1.18; P = 0.002], whereas lymphovascular invasion was significantly associated with poor DSS (HR = 33.66; 95% CI 3.05-371.25; P = 0.004).

Conclusion: This study shows that HER2 overexpression is significantly associated with tumor recurrence in pN0 EGC. Hence, Her2 testing at diagnosis is important and differential treatment and/or follow up strategies for patients with Her2 overexpression may merit future study.

Keywords: Early gastric cancer; Human epidermal growth factor receptor 2; Mortality; Overexpression; Tumor recurrence.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Kaplan–Meier curves for overall survival
Fig. 2
Fig. 2
Kaplan–Meier curves for disease specific survival
Fig. 3
Fig. 3
Kaplan–Meier curves for tumor recurrence
See this image and copyright information in PMC

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