The Role of H2S Regulating NLRP3 Inflammasome in Diabetes
- PMID: 35563208
- PMCID: PMC9103162
- DOI: 10.3390/ijms23094818
The Role of H2S Regulating NLRP3 Inflammasome in Diabetes
Abstract
Nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) is a recently discovered cytoplasmic multiprotein complex involved in inflammation. The NLRP3 inflammasome contains NLRP3, apoptosis-related specific protein (ASC) and precursor caspase-1. The NLRP3 inflammasome is involved in many diseases, including diabetes. H2S is a harmful gas with a rotten egg smell. Recently, it has been identified as the third gas signal molecule after nitric oxide and carbon monoxide. It has many biological functions and plays an important role in many diseases, including diabetes. In recent years, it has been reported that H2S regulation of the NLRP3 inflammasome contributes to a variety of diseases. However, the mechanism has not been fully understood. In this review, we summarized the recent role and mechanism of H2S in regulating the NLRP3 inflammasome in diabetes, in order to provide a theoretical basis for future research.
Keywords: NLRP3 inflammasome; diabetes-accelerated atherosclerosis; diabetic cardiomyopathy; diabetic retinopathy; hydrogen sulfide.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Similar articles
-
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.Mol Cell Biochem. 2025 Jun;480(6):3813-3839. doi: 10.1007/s11010-025-05220-3. Epub 2025 Feb 8. Mol Cell Biochem. 2025. PMID: 39921790
-
Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome.Int J Biol Sci. 2020 Aug 25;16(14):2752-2760. doi: 10.7150/ijbs.47595. eCollection 2020. Int J Biol Sci. 2020. PMID: 33110394 Free PMC article. Review.
-
Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart.Basic Res Cardiol. 2020 Jan 7;115(2):10. doi: 10.1007/s00395-019-0771-9. Basic Res Cardiol. 2020. PMID: 31912235 Free PMC article.
-
Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome.Mol Neurobiol. 2016 Jul;53(5):3462-3476. doi: 10.1007/s12035-015-9242-y. Epub 2015 Jun 20. Mol Neurobiol. 2016. PMID: 26091790
-
Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling.Immunol Cell Biol. 2017 Aug;95(7):584-592. doi: 10.1038/icb.2017.23. Epub 2017 Mar 30. Immunol Cell Biol. 2017. PMID: 28356568 Review.
Cited by
-
Dencichine attenuates the virulence of Fusobacterium nucleatum by targeting hydrogen sulfide-producing enzyme.Int Microbiol. 2025 Feb;28(2):257-264. doi: 10.1007/s10123-024-00539-1. Epub 2024 May 25. Int Microbiol. 2025. PMID: 38789725
-
Novel ray of hope for diabetic wound healing: Hydrogen sulfide and its releasing agents.J Adv Res. 2024 Apr;58:105-115. doi: 10.1016/j.jare.2023.05.009. Epub 2023 May 27. J Adv Res. 2024. PMID: 37245638 Free PMC article. Review.
-
The Protective Role of Baicalin in the Regulation of NLRP3 Inflammasome in Different Diseases.Cell Biochem Biophys. 2025 Jun;83(2):1387-1397. doi: 10.1007/s12013-024-01597-y. Epub 2024 Oct 23. Cell Biochem Biophys. 2025. PMID: 39443419 Review.
-
Portrayal of NLRP3 Inflammasome in Atherosclerosis: Current Knowledge and Therapeutic Targets.Int J Mol Sci. 2023 May 3;24(9):8162. doi: 10.3390/ijms24098162. Int J Mol Sci. 2023. PMID: 37175869 Free PMC article. Review.
-
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.Mol Cell Biochem. 2025 Jun;480(6):3813-3839. doi: 10.1007/s11010-025-05220-3. Epub 2025 Feb 8. Mol Cell Biochem. 2025. PMID: 39921790
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous