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Review
. 2022 Apr 27;23(9):4818.
doi: 10.3390/ijms23094818.

The Role of H2S Regulating NLRP3 Inflammasome in Diabetes

Huijie Zhao  1   2 , Huiyang Liu  1 , Yihan Yang  1 , Honggang Wang  1
Affiliations
Review

The Role of H2S Regulating NLRP3 Inflammasome in Diabetes

Huijie Zhao et al. Int J Mol Sci. .

Abstract

Nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) is a recently discovered cytoplasmic multiprotein complex involved in inflammation. The NLRP3 inflammasome contains NLRP3, apoptosis-related specific protein (ASC) and precursor caspase-1. The NLRP3 inflammasome is involved in many diseases, including diabetes. H2S is a harmful gas with a rotten egg smell. Recently, it has been identified as the third gas signal molecule after nitric oxide and carbon monoxide. It has many biological functions and plays an important role in many diseases, including diabetes. In recent years, it has been reported that H2S regulation of the NLRP3 inflammasome contributes to a variety of diseases. However, the mechanism has not been fully understood. In this review, we summarized the recent role and mechanism of H2S in regulating the NLRP3 inflammasome in diabetes, in order to provide a theoretical basis for future research.

Keywords: NLRP3 inflammasome; diabetes-accelerated atherosclerosis; diabetic cardiomyopathy; diabetic retinopathy; hydrogen sulfide.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram of the NLRP3 inflammasome activation process.
Figure 2
Figure 2
Summary of the production of endogenous H2S. CBS: cystathionine-beta-synthase; CSE: cystathionine-gamma-lyase; 3-MST: 3-mercaptopyruvate thiotransferase; 3-MP: 3-mercaptopyruvate; CAT: cysteine aminotransferase.
See this image and copyright information in PMC

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