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Editorial
. 2022 Apr 30;23(9):5025.
doi: 10.3390/ijms23095025.

PPARs as Key Mediators in the Regulation of Metabolism and Inflammation

Manuel Vázquez-Carrera  1   2 , Walter Wahli  3   4   5
Affiliations
Editorial

PPARs as Key Mediators in the Regulation of Metabolism and Inflammation

Manuel Vázquez-Carrera et al. Int J Mol Sci. .

Abstract

Nuclear receptors (NRs) form a large family of ligand-dependent transcription factors that control the expression of a multitude of genes involved in diverse, vital biological processes [...].

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Modes of action of PPARs in transcription transactivation and transrepression (only one of the several mechanisms of transrepression is shown). A non-exhaustive list of the target organs subjected to PPAR-mediated metabolic and inflammatory regulation is shown. The reference numbers (in blue and in parentheses) refer to the articles quoted in this Special Issue (see References); in the figure, they are listed and grouped according to the topic addressed in the corresponding articles. PPRE: peroxisome proliferator hormone response element. p65 subunit of NF-κB. RXR: retinoid X receptor.
See this image and copyright information in PMC

References

    1. Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 1990;347:645–650. doi: 10.1038/347645a0. - DOI - PubMed
    1. Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell. 1992;68:879–887. doi: 10.1016/0092-8674(92)90031-7. - DOI - PubMed
    1. Tan C.K., Zhuang Y., Wahli W. Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome. Expert Opin. Ther. Targets. 2017;21:333–348. doi: 10.1080/14728222.2017.1280467. - DOI - PubMed
    1. Wahli W., Michalik L. PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol. Metab. 2012;23:351–363. doi: 10.1016/j.tem.2012.05.001. - DOI - PubMed
    1. Perez Diaz N., Lione L.A., Hutter V., Mackenzie L.S. Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery. Int. J. Mol. Sci. 2021;22:3158. doi: 10.3390/ijms22063158. - DOI - PMC - PubMed

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