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Meta-Analysis
. 2022 Apr 21;19(9):5048.
doi: 10.3390/ijerph19095048.

Oral Health Status in Marfan Syndrome: A Systematic Review and Meta-Analysis of 353 Cases

Mohammad Khursheed Alam  1 , Ahmed Ali Alfawzan  2 , Deepti Shrivastava  3 , Kumar Chandan Srivastava  4 , Haytham Jamil Alswairki  5 , Samir Mussallam  6 , Huda Abutayyem  7 , Naseer Ahmed  8   9
Affiliations
Meta-Analysis

Oral Health Status in Marfan Syndrome: A Systematic Review and Meta-Analysis of 353 Cases

Mohammad Khursheed Alam et al. Int J Environ Res Public Health. .

Abstract

This meta-analysis aimed to compare Marfan syndrome (MFS) patients with non-MFS populations based on orofacial health status to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, for articles published between 1 January 2000 and 17 February 2022. PRISMA guidelines were followed to carry out this systematic review. We used the PECO system to classify people with MFS based on whether or not they had distinctive oral health characteristics compared to the non-MFS population. The following are some examples of how PECO is used: P denotes someone who has MFS; E stands for a medical or genetic assessment of MFS; C stands for people who do not have MFS; and O stands for the orofacial characteristics of MFS. Using the Newcastle-Ottawa Quality Assessment Scale, independent reviewers assessed the articles' methodological quality and extracted data. Four case-control studies were analyzed for meta-analysis. Due to the wide range of variability, we were only able to include data from at least three previous studies. There was a statistically significant difference in bleeding on probing and pocket depth between MFS and non-MFS subjects. MFS patients are more prone to periodontal tissue inflammation due to the activity of FBN1 and MMPs. Early orthodontic treatment is beneficial for the correction of a narrow upper jaw and a high palate, as well as a skeletal class II with retrognathism of the lower jaw and crowding of teeth.

Keywords: Marfan syndrome; meta-analysis; oral health; orofacial health status; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Genes and mutations commonly found in MFS.
Figure 2
Figure 2
Common oral features found in MFS (Courtesy of Dr. M. K. Alam).
Figure 3
Figure 3
Keywords used for data searching.
Figure 4
Figure 4
PRISMA flowchart.
Figure 5
Figure 5
Forest plot of (A) DMFT, (B) pocket depth (PD), and (C) bleeding on probing (BOP) [8,9,17,22,23].
Figure 6
Figure 6
Risk of bias assessment visualization [8,9,17,18,19,20,21,22,23,24].
Figure 7
Figure 7
Funnel plot for publication bias in (a) DMFT, (b) pocket depth, and (c) bleeding on probing.
See this image and copyright information in PMC

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