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. 2022 Apr 29;19(9):5454.
doi: 10.3390/ijerph19095454.

Renal Function in Patients with Cystic Fibrosis: A Single-Center Study

Marta Rachel  1   2 , Sabina Galiniak  2 , Marek Biesiadecki  2 , Agnieszka Gala-Błądzińska  2   3
Affiliations

Renal Function in Patients with Cystic Fibrosis: A Single-Center Study

Marta Rachel et al. Int J Environ Res Public Health. .

Abstract

Cystic fibrosis (CF) is the most common incurable autosomal recessive disease affecting the Caucasian population. As the prognosis for life extension of CF patients improves, co-morbidities, including kidney disease, become more common. Identifying those at the highest risk of kidney injury is therefore extremely important. The aim of this study was to evaluate the biomarkers of renal function in 50 CF patients using the estimated glomerular filtration rate (eGFR) based on creatinine and cystatin C equation as well as serum creatinine (sCr), serum cystatin C (CysC), serum urea and urinary neutrophil gelatinase-associated lipocalin (uNGAL) concentrations. sCr, CysC, urea and uNGAL were estimated. eGFR was calculated according to the CKD-EPI formula. CysC was significantly increased, while eGFR was significantly lower in the CF group than in the controls (p < 0.001 and p < 0.01, respectively). There was no significant difference in the sCr, urea and uNGAL concentrations between patients with CF and healthy subjects. For the purpose of our analysis, in order to assess renal function in patients with CF in clinical practice, the concentration of serum CysC and eGFRCKD-EPI should be determined. Patients with CF presented with renal function impairment pictured by increased serum CysC and decreased eGFR values compared to controls. Unchanged uNGAL concentrations suggested preserved tubular function despite aminoglycoside treatment. Further prospective studies are needed to clarify whether kidney impairment observed in the course of CF progresses.

Keywords: cystic fibrosis; drug nephrotoxicity; kidney injury.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of number of patients recruited and analyzed in the study.
Figure 2
Figure 2
eGFRCKD-EPI in patients with CF and healthy controls.
Figure 3
Figure 3
Urine NGAL concentration in patients with CF and healthy controls (p > 0.05).
Figure 4
Figure 4
Relationship between urine NGAL and eGFRCKD-EPI Cystatin C in participants with CF (p = 0.272).
See this image and copyright information in PMC

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