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. 2022 May 4;19(9):5585.
doi: 10.3390/ijerph19095585.

Persistence of Adverse Drug Reaction-Related Hospitalization Risk Following Discharge

Olive Schmid  1 , Bonnie Bereznicki  2 , Gregory Mark Peterson  1 , Jim Stankovich  1 , Luke Bereznicki  1
Affiliations

Persistence of Adverse Drug Reaction-Related Hospitalization Risk Following Discharge

Olive Schmid et al. Int J Environ Res Public Health. .

Abstract

This retrospective cohort study analyzed the administrative hospital records of 91,500 patients with the aim of assessing adverse drug reaction (ADR)-related hospital admission risk after discharge from ADR and non-ADR-related admission. Patients aged ≥18 years with an acute admission to public hospitals in Tasmania, Australia between 2011 and 2015 were followed until May 2017. The index admissions (n = 91,550) were stratified based on whether they were ADR-related (n = 2843, 3.1%) or non-ADR-related (n = 88,707, 96.9%). Survival analysis assessed the post-index ADR-related admission risk using (1) the full dataset, and (2) a matched subset of patients using a propensity score analysis. Logistic regression was used to identify the risk factors for ADR-related admissions within 90 days of post-index discharge. The patients with an ADR-related index admission were almost five times more likely to experience another ADR-related admission within 90 days (p < 0.001). An increased risk persisted for at least 5 years (p < 0.001), which was substantially longer than previously reported. From the matched subset of patients, the risk of ADR-related admission within 90 and 365 days more than doubled in the patients with an ADR-related index admission (p < 0.0001). These admissions were often attributed to the same drug class as the patients’ index ADR-related admission. Cancer was a major risk factor for ADR-related re-hospitalization within 90 days; other factors included heart failure and increasing age.

Keywords: adverse drug event; adverse drug reactions; hospital admission; medication errors; medication safety; risk factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure A1
Figure A1
Risk of an ADR-related admission after index discharge for patients with ADR compared to non-ADR-related index admissions.
Figure 1
Figure 1
Probability of post-index ADR-related admission for patients with ADR compared to non-ADR-related index admissions.
Figure 2
Figure 2
Relative risk of a post-index ADR-related admission for patients with ADR compared to non-ADR-related index admissions. Bars represent 95% confidence intervals.
See this image and copyright information in PMC

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