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Randomized Controlled Trial
. 2022 May 7;19(9):5709.
doi: 10.3390/ijerph19095709.

Mediterranean Style Dietary Pattern with High Intensity Interval Training in Men with Prostate Cancer Treated with Androgen Deprivation Therapy: A Pilot Randomised Control Trial

Brenton J Baguley  1   2 , Kirsten Adlard  2 , David Jenkins  2   3   4 , Olivia R L Wright  2   5 , Tina L Skinner  2
Affiliations
Randomized Controlled Trial

Mediterranean Style Dietary Pattern with High Intensity Interval Training in Men with Prostate Cancer Treated with Androgen Deprivation Therapy: A Pilot Randomised Control Trial

Brenton J Baguley et al. Int J Environ Res Public Health. .

Abstract

Background: Androgen deprivation therapy (ADT) in prostate cancer has been shown to deteriorate body composition (reduced lean mass and increased body and fat mass) and increase the risk of cardiovascular morbidity. The Mediterranean style dietary pattern (MED-diet) and high intensity interval training (HIIT) may synergistically alleviate these side effects and improve quality of life in men treated with ADT. Methods: Twenty-three men (65.9 ± 7.8 years; body mass index: 29.6 ± 2.7 kg/m2; ADT duration: 33.8 ± 35.6 months) receiving ADT for ≥3 months were randomly assigned (1:1) to 20 weeks of usual care or the MED-diet (10 nutrition consults) with HIIT (4 × 4 min 85−95% heart rate peak, 3× week, starting at 12 weeks). Results: The MED-diet with HIIT significantly improved cardiorespiratory fitness (+4.9 mL·kg−1·min, p < 0.001), and body mass (−3.3 kg, p < 0.001) compared to the usual care group at 20 weeks. Clinically meaningful (≥3 points) improvements were seen in quality of life and cancer-related fatigue after 20 weeks. Conclusions: The MED-diet with HIIT increased cardiorespiratory fitness and reduced body weight in men with prostate cancer treated with ADT. Larger trials determining whether the MED-diet with HIIT translates to cardiovascular benefits are warranted.

Keywords: androgen deprivation therapy; high intensity interval training; mediterranean diet; prostate cancer.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
CONSORT diagram and schematic representation of the study. Legend: MED-diet = Mediterranean-style dietary pattern; HIIT = high intensity interval training; Wk = week.
Figure 2
Figure 2
CONSORT diagram illustrating participant flow through the intervention. ADT: androgen deprivation therapy; MED-diet: Mediterranean-style dietary pattern; HIIT: high intensity interval training.
See this image and copyright information in PMC

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