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. 2022 Apr 24;14(9):2117.
doi: 10.3390/cancers14092117.

Comparison of Survival Outcomes between Minimally Invasive Surgery and Open Radical Hysterectomy in Early-Stage Cervical Cancer

I-Ning Chen  1 , I-Te Wang  1 , Hsueh-Yu Mu  1 , J-Timothy Qiu  1   2   3 , Wei-Min Liu  1   2 , Ching-Wen Chang  1 , Yen-Hsieh Chiu  1
Affiliations

Comparison of Survival Outcomes between Minimally Invasive Surgery and Open Radical Hysterectomy in Early-Stage Cervical Cancer

I-Ning Chen et al. Cancers (Basel). .

Abstract

Objectives: To compare the survival outcomes between minimally invasive surgery (MIS) and laparotomy radical hysterectomy in patients with early-stage cervical cancer.

Methods: We conducted a retrospective study involving women who received a radical hysterectomy for cervical cancer, stage IA1 with lymphovascular invasion, IA2, IB1, IB2, or IIA from 2008 to 2016. Clinicopathologic and perioperative outcomes were compared using appropriate statistical methodologies.

Results: Oncologic survival outcomes were analyzed using the Kaplan-Meier method. Among the 105 cases identified, 58 (55.2%) and 47 (44.8%) women underwent MIS and open radical hysterectomy, respectively. Over a median follow-up period of 62 months, women who underwent MIS and open radical hysterectomy had a 5-year overall survival rate of 87.9% and 89.4% (p = 0.845) and a 5-year disease-free survival rate of 82.5% and 86.7% (p = 0.624), respectively.

Conclusions: For early-stage cervical cancer, patients who underwent MIS radical hysterectomy had survival outcomes that were comparable to those who underwent open surgery at our institute.

Keywords: cervical cancer; hysterectomy; laparoscopic surgery; laparotomy radical hysterectomy; minimally invasive surgery; robotic-assisted surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Oncologic outcomes of minimally invasive surgery (MIS) versus open radical hysterectomy: (a) 5-year disease-free survival; (b) 5-year overall survival.
Figure 2
Figure 2
Oncologic outcomes of MIS versus open radical hysterectomy with pathologic tumor size ≤ 2 cm: (a) 5-year disease-free survival; (b) 5-year overall survival.
Figure 3
Figure 3
Oncologic outcomes of MIS versus open radical hysterectomy with pathologic tumor size > 2 cm: (a) 5-year disease-free survival; (b) 5-year overall survival.
See this image and copyright information in PMC

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References

    1. Nadeem R.M. Cervical Cancer, v1, 2021. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) 2021. [(accessed on 8 August 2021)]. Available online: https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1426.
    1. Nezhat C.R., Burrell M.O., Nezhat F.R., Benigno B.B., Welander C.E. Laparoscopic radical hysterectomy with paraaortic and pelvic node dissection. Am. J. Obstet. Gynecol. 1992;166:864–865. doi: 10.1016/0002-9378(92)91351-A. - DOI - PubMed
    1. Alfonzo E., Wallin E., Ekdahl L., Staf C., Rådestad A.F., Reynisson P., Stålberg K., Falconer H., Persson J., Dahm-Kähler P. No survival difference between robotic and open radical hysterectomy for women with early-stage cervical cancer: Results from a nationwide population-based cohort study. Eur. J. Cancer. 2019;116:169–177. doi: 10.1016/j.ejca.2019.05.016. - DOI - PubMed
    1. Shazly S.A., Murad M.H., Dowdy S.C., Gostout B.S., Famuyide A.O. Robotic radical hysterectomy in early stage cervical cancer: A systematic review and meta-analysis. Gynecol. Oncol. 2015;138:457–471. doi: 10.1016/j.ygyno.2015.06.009. - DOI - PubMed
    1. Sert B., Boggess J., Ahmad S., Jackson A., Stavitzski N., Dahl A., Holloway R.W. Robot-assisted versus open radical hysterectomy: A multi-institutional experience for early-stage cervical cancer. Eur. J. Surg. Oncol. 2016;42:513–522. doi: 10.1016/j.ejso.2015.12.014. - DOI - PubMed

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