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Review
. 2022 May 8;14(9):2332.
doi: 10.3390/cancers14092332.

Peripheral T-Cell Lymphomas: Therapeutic Approaches

David Sibon  1   2
Affiliations
Review

Peripheral T-Cell Lymphomas: Therapeutic Approaches

David Sibon. Cancers (Basel). .

Abstract

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of rare neoplasms of mature T cells or natural killer (NK) cell. PTCLs usually have an aggressive course and a poor outcome. In recent years, significant progress has been made in the knowledge of the molecular lymphomagenesis of PTCLs, and through the development of new, more specific therapeutic molecules, one can hope in the coming years for more personalized medicine and improved patient prognosis. This review aims to provide an up-to-date overview of the current therapeutic approaches in nodal PTCLs.

Keywords: BV-CHP; CHOEP; CHOP; PTCL; hematopoietic stem-cell transplantation; targeted treatments.

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Conflict of interest statement

The author wishes to disclose the following professional affiliations: consultancies with AbbVie, iQone Healthcare, Janssen, Roche, and Takeda.

Figures

Figure 1
Figure 1
Classification of mature T- and NK-cell neoplasms according to the 2017 WHO classification.
Figure 2
Figure 2
Proposed algorithm of frontline treatment in nodal PTCLs. This algorithm is based on histological subtype, transplant-eligibility, and prognostic factors.
See this image and copyright information in PMC

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