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Review
. 2022 Apr 23;12(9):1098.
doi: 10.3390/ani12091098.

Mining the Proteome of Toxoplasma Parasites Seeking Vaccine and Diagnostic Candidates

Sajad Rashidi  1 , Javier Sánchez-Montejo  2 , Reza Mansouri  3 , Mohammad Ali-Hassanzadeh  4 , Amir Savardashtaki  5 , Mohammad Saleh Bahreini  1 , Mohammadreza Karimazar  1 , Raúl Manzano-Román  2 , Paul Nguewa  6
Affiliations
Review

Mining the Proteome of Toxoplasma Parasites Seeking Vaccine and Diagnostic Candidates

Sajad Rashidi et al. Animals (Basel). .

Abstract

Toxoplasma gondii is a pathogenic protozoan parasite that infects the nucleated cells of warm-blooded hosts leading to an infectious zoonotic disease known as toxoplasmosis. The infection outcomes might be severe and fatal in patients with immunodeficiency, diabetes, and pregnant women and infants. The One Health approach to toxoplasmosis highlights that the health of humans is closely related to the health of animals and our common environment. The presence of drug resistance and side effects, the further improvement of sensitivity and specificity of serodiagnostic tools and the potentiality of vaccine candidates to induce the host immune response are considered as justifiable reasons for the identification of novel targets for the better management of toxoplasmosis. Thus, the identification of new critical proteins in the proteome of Toxoplasma parasites can also be helpful in designing and test more effective drugs, vaccines, and diagnostic tools. Accordingly, in this study we present important proteins found in the proteome of the life cycle-specific stages of Toxoplasma parasites that are potential diagnostic or vaccine candidates. The current study might help to understand the complexity of these parasites and provide a possible source of strategies and biomolecules that can be further evaluated in the pathobiology of Toxoplasma parasites and for diagnostics and vaccine trials against this disease.

Keywords: Toxoplasma gondii; diagnostics; targets; toxoplasmosis; vaccines.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Proteomic techniques mainly used for the identification of T. gondii proteome.
Figure 2
Figure 2
Toxoplasma vaccine and diagnostic candidates inferred from proteomics data.
Figure 3
Figure 3
Proteins identified in the proteome of important structures of the Toxoplasma parasite.
See this image and copyright information in PMC

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