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. 2022 Apr 21;14(9):1720.
doi: 10.3390/nu14091720.

Partial Hydrolyzed Protein as a Protein Source for Infant Feeding: Do or Don't?

Yvan Vandenplas  1 , Janusz Ksiażyk  2 , Manuel Sanchez Luna  3 , Natalia Migacheva  4 , Jean-Charles Picaud  5   6 , Luca A Ramenghi  7 , Atul Singhal  8 , Martin Wabitsch  9
Affiliations

Partial Hydrolyzed Protein as a Protein Source for Infant Feeding: Do or Don't?

Yvan Vandenplas et al. Nutrients. .

Abstract

Exclusive breastfeeding until the age of six months is the recommended feeding method for all infants. However, this is not possible for every infant. Therefore, a second choice of feeding, as close as possible to the gold standard, is needed. For historical reasons, this has been cow's-milk-based feeding. This paper discusses if this second-choice feeding method should contain intact protein or partially hydrolyzed proteins. The limited data available indicates that mother's milk is relatively rich in bioactive peptides. Whether partially hydrolyzed protein might be a protein source closer to human milk protein content than intact cow's milk needs further research. However, more research on protein and bioactive peptides in mother's milk should be a priority for future scientific development in this field. Results of such research will also provide an answer to the question of which option would be the best second choice for infant feeding if sufficient breast milk is not available.

Keywords: breastfeeding; functional gastrointestinal disorder; partial hydrolysate; peptide; prevention; protein.

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Conflict of interest statement

J.K.: Lectures for: BBraun, Fresenius Kabi, Nestle, Nutricia; N.M.: participation as advisory board member for Nestlé Nutrition Institute; J.-C.P.: clinical investigator, and/or advisory board member, and/or speaker for Nestlé Research, Bledina, Nestlé Nutrition Institute, Medela; A.S.: research funding from Nestlé and Abbott Plc; and honoraria to give lectures and attend advisory boards for Nestlé Nutrition Institute, Danone, Wyeth Nutrition, Reckitt, Phillips, Abbott Nutrition and Academic Institutions; M.W.: NNI European Advisory Board; M.S.L.: Advisory Board from Nestle; L.A.R. and Y.V. declare no conflict of interest.

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