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Randomized Controlled Trial
. 2022 Apr 22;14(9):1763.
doi: 10.3390/nu14091763.

A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine

Jemima S A Dzator  1 , Peter R C Howe  1   2   3 , Kirsten G Coupland  1   4 , Rachel H X Wong  1   3
Affiliations
Randomized Controlled Trial

A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine

Jemima S A Dzator et al. Nutrients. .

Abstract

Resveratrol, a vasoactive phytoestrogen, has beneficial effects on cerebrovascular function. Previous research has shown that hormonal migraineurs have poorer cerebrovascular function than non-migraineur women. We aimed to investigate if resveratrol supplementation for three months could reduce the hormonal migraine burden index (HMBI: the number of days with menstrual migraine per month), reduce migraine-related disability and improve migraine-related quality of life. A randomised, double-blind, placebo-controlled, crossover, intervention trial was conducted in 62 hormonal migraineurs (mean age: 37.5 ± 0.8 years). Participants consumed 75 mg of resveratrol or matching placebo capsules twice daily for three months before crossing over to the other treatment arm. Participants completed a daily diary and the Headache Impact Test-6™, Migraine Disability Assessment and Migraine-Specific Quality of Life questionnaires at months 0, 3 and 6. The HMBI was the primary outcome and was calculated using data extracted from the participant's diary. No differences in the HMBI (p = 0.895), the Headache Impact Test-6™, the Migraine Disability Assessment and Migraine-Specific Quality of Life were found between the resveratrol and placebo treatments. Resveratrol supplementation for three months did not affect the HMBI, the migraine-related disability or quality of life measures in our cohort of hormonal migraineurs.

Keywords: cerebrovascular function; hormonal migraine; migraine disability assessment; nutrient intervention; phytoestrogen; prophylaxis; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest. Whilst Evolva SA (Basel, Switzerland) provided study materials and funding, they were not involved in the study conception and design or the collection, analysis and interpretation of the data.

Figures

Figure 1
Figure 1
CONSORT diagram depicting flow of study participants.
See this image and copyright information in PMC

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