Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 24;14(9):1789.
doi: 10.3390/nu14091789.

The Association between Serum Resistin Level, Resistin (-420C/G) Single Nucleotide Variant, and Markers of Endothelial Dysfunction, including Salt Taste Preference in Hypertensive Patients

Katarzyna Musialik  1 , Ewa Miller-Kasprzak  1 , Marta Walczak  2 , Leszek Markuszewski  3 , Paweł Bogdański  1
Affiliations

The Association between Serum Resistin Level, Resistin (-420C/G) Single Nucleotide Variant, and Markers of Endothelial Dysfunction, including Salt Taste Preference in Hypertensive Patients

Katarzyna Musialik et al. Nutrients. .

Abstract

Background: Resistin action links to conditions such as diabetes, obesity, but its role in hypertension is less well understood. This study aimed to estimate the relationship between resistin (-420G/C) single nucleotide variant (SNV) and markers associated with endothelial dysfunction in hypertension. Methods: The study enrolled 162 hypertensive patients (HT) and 165 non-hypertensive (NHT) patients. Resistin serum concentration was estimated with immuoenzymatic assay. Anthropometric measurements, blood pressure and arterial stiffness index (SI), uric acid (UA) serum concentration, and salty taste preference of normal (NS) or high (HS) were assessed in the study. Genotyping was achieved by polymerase chain reaction-restriction fragment length polymorphism. Results: Resistin concentration and SI do not differ significantly between HT and NHT individuals; UA significantly increased in HT subjects. Resistin, UA, and SI did not differ among particular resistin genotypes in HT, NHT, NS, or HS groups. GG and CG genotypes were more frequent (OR 1.57 (95% CI; 1.01-2.43); p = 0.04) in hypertensive individuals than the NHT group, but less frequent (OR 0.58 (95% CI; 0.37-0.91); p = 0.01) in HS patients compared to NS individuals. Concerning HT patients with different salt preferences, GG + CG genotypes were less frequent (OR 0.50 (95% CI; 0.26-0.97); p = 0.04) in the HS group than in NS individuals. HT carriers of GG and CG genotype have significantly increased UA concentrations compared to the respective NHT subjects. HS individuals carrying GG and CG genotypes have higher SI values than the NS group. Allele G of SNV (-420G/C) adjusted for age, BMI, serum resistin, UA concentration, salt taste preference, SI, and HR values increased the risk of developing hypertensive phenotype 1.8 fold. Conclusions: Resistin SNV (-420G/C) is related to several markers associated with endothelial dysfunction, including salt taste preference in hypertensive patients.

Keywords: arterial stiffness; endothelial dysfunction; hypertension; obesity; resistin polymorphism; salt intake; uric acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Zhou B., Bentham J., Di Cesare M., Bixby H., Danaei G., Cowan M.J., Paciorek C.J., Singh G., Hajifathalian K., Bennett J.E., et al. Worldwide trends in blood pressure from 1975 to 2015: A pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Lancet. 2017;389:37–55. doi: 10.1016/S0140-6736(16)31919-5. - DOI - PMC - PubMed
    1. Chow C.K., Teo K.K., Rangarajan S., Islam S., Gupta R., Avezum A., Bahonar A., Chifamba J., Dagenais G., Diaz R., et al. Prevalence, Awareness, Treatment, and Control of Hypertension in Rural and Urban Communities in High-, Middle-, and Low-Income Countries. JAMA. 2013;310:959–968. doi: 10.1001/jama.2013.184182. - DOI - PubMed
    1. Kearney P.M., Whelton M., Reynolds K., Muntner P., Whelton P.K., He J. Global burden of hypertension: Analysis of worldwide data. Lancet. 2005;365:217–223. doi: 10.1016/S0140-6736(05)17741-1. - DOI - PubMed
    1. Franco O.H., Peeters A., Bonneux L., de Laet C. Blood Pressure in Adulthood and Life Expectancy with Cardiovascular Disease in Men and Women. Hypertension. 2005;46:280–286. doi: 10.1161/01.HYP.0000173433.67426.9b. - DOI - PubMed
    1. Alderman M.H., Cohen H.W. Dietary Sodium Intake and Cardiovascular Mortality: Controversy Resolved? Am. J. Hypertens. 2012;25:727–734. doi: 10.1038/ajh.2012.52. - DOI - PubMed