Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 30;14(9):1897.
doi: 10.3390/nu14091897.

Gastric Mobility and Gastrointestinal Hormones in Older Patients with Sarcopenia

Hsien-Hao Huang  1   2   3 , Tse-Yao Wang  1   3 , Shan-Fan Yao  4 , Pei-Ying Lin  1   3 , Julia Chia-Yu Chang  1   3 , Li-Ning Peng  5   6 , Liang-Kung Chen  5   6   7 , David Hung-Tsang Yen  1   2   3   8   9
Affiliations

Gastric Mobility and Gastrointestinal Hormones in Older Patients with Sarcopenia

Hsien-Hao Huang et al. Nutrients. .

Abstract

Sarcopenia has serious clinical consequences and poses a major threat to older people. Gastrointestinal environmental factors are believed to be the main cause. The aim of this study was to describe the relationship between sarcopenia and gastric mobility and to investigate the relationship between sarcopenia and the concentration of gastrointestinal hormones in older patients. Patients aged ≥ 75 years were recruited for this prospective study from August 2018 to February 2019 at the emergency department. The enrolled patients were tested for sarcopenia. Gastric emptying scintigraphy was conducted, and laboratory tests for cholecystokinin(CCK), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), nesfatin, and ghrelin were performed during the fasting period. We enrolled 52 patients with mean age of 86.9 years, including 17 (32.7%) patients in the non-sarcopenia group, 17 (32.7%) patients in the pre-sarcopenia group, and 18 (34.6%) in the sarcopenia group. The mean gastric emptying half-time had no significant difference among three groups. The sarcopenia group had significantly higher fasting plasma concentrations of CCK, GLP-1, and PYY. We concluded that the older people with sarcopenia had significantly higher plasma concentrations of CCK, GLP-1, and PYY. In the elderly population, anorexigenic gastrointestinal hormones might have more important relationships with sarcopenia than orexigenic gastrointestinal hormones.

Keywords: gastric emptying; gastrointestinal hormones; older patients; sarcopenia.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Beaudart C., Rizzoli R., Bruyère O., Reginster J.Y., Biver E. Sarcopenia: Burden and challenges for public health. Arch. Public Health. 2014;72:45. doi: 10.1186/2049-3258-72-45. - DOI - PMC - PubMed
    1. Chen L.K., Woo J., Assantachai P., Auyeung T.W., Chou M.Y., Iijima K., Jang H.C., Kang L., Kim M., Kim S., et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J. Am. Med. Dir. Assoc. 2020;21:300–307.e2. doi: 10.1016/j.jamda.2019.12.012. - DOI - PubMed
    1. Cruz-Jentoft A.J., Bahat G., Bauer J., Boirie Y., Bruyère O., Cederholm T., Cooper C., Landi F., Rolland Y., Sayer A.A., et al. Sarcopenia: Revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16–31. doi: 10.1093/ageing/afy169. - DOI - PMC - PubMed
    1. Lee J.S., Auyeung T.W., Kwok T., Lau E.M., Leung P.C., Woo J. Associated factors and health impact of sarcopenia in older chinese men and women: A cross-sectional study. Gerontology. 2007;53:404–410. doi: 10.1159/000107355. - DOI - PubMed
    1. Mijnarends D.M., Luiking Y.C., Halfens R.J.G., Evers S.M.A.A., Lenaerts E.L.A., Verlaan S., Wallace M., Schols J.M.G.A., Meijers J.M.M. Muscle, Health and Costs: A Glance at their Relationship. J. Nutr. Health Aging. 2018;22:766–773. doi: 10.1007/s12603-018-1058-9. - DOI - PMC - PubMed

LinkOut - more resources