Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 5;27(9):2949.
doi: 10.3390/molecules27092949.

Investigation of Chemical Compositions and Biological Activities of Mentha suaveolens L. from Saudi Arabia

Bashayr Aldogman  1 , Hallouma Bilel  1 , Shaima Mohamed Nabil Moustafa  2 , Khaled F Elmassary  3 , Hazim M Ali  1 , Faddaa Qayid Alotaibi  1 , Mohamed Hamza  2 , Mohamed A Abdelgawad  4 , Ahmed H El-Ghorab  1
Affiliations

Investigation of Chemical Compositions and Biological Activities of Mentha suaveolens L. from Saudi Arabia

Bashayr Aldogman et al. Molecules. .

Abstract

Mentha is an aromatic plant used since antiquity for its pharmaceutical virtues. The climate of Saudi Arabia favors the growth of aromatic plants including Mentha suaveolens L. The aim of this study is to analyze the volatile oils of different parts of fresh and dried Mentha suaveolens L. grown in Saudi Arabia (Aljouf area) using Gas Chromatography/Mass Spectrometry (GC/MS) and Gas Chromatography Flame Ionization Detector (GC/FID) techniques, to recognize the effect of drying on chemical composition, then to evaluate the antioxidant and antifungal activities of different extracts. In total, 118 compounds were identified via GC/MS and GC/FID, in which carvone is the main volatile constituent (stems, leaves, whole plant 45-64%). This investigation deduces that Mentha belonged to the carvone chemotype. Then, the analysis of non-volatile constituents of fresh and dried Mentha was performed by HPLC. The main phenolic compound of fresh and dried Mentha for different parts was rosmarinic acid (ranging from 28,002.5 to 6558 µg/g). The ethanolic extract of fresh stem showed the highest antifungal activity (53% inhibition) compared with miconazole (60% inhibition) but the ethanoic extract of dry stem showed no activity. Additionally, all ethanolic extracts, whether for fresh or dry Mentha, have antioxidant activity more than 90% while the antioxidant activity of whole plant volatile oil is equal to 53.33%. This research shows that M. suaveolens L. could be applied to manufacture natural antioxidants, antifungal, and flavoring agents.

Keywords: Mentha suaveolens L.; antifungal activity; antioxidant; carvone; rosmarinic acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Drying effect on volatile oils constituents of M. suaveolens L. Sesquiterpenes (S), heavy oxygenated compounds (HOC), light oxygenated compounds (LOC), and monoterpenes (M).
Figure 2
Figure 2
Antioxidant activity of volatile oils of M. suaveolens L.
Figure 3
Figure 3
Antioxidant activity of non-volatile constituents of M. suaveolens L.
Figure 4
Figure 4
Antifungal activity of volatile oils of M. suaveolens L.
Figure 5
Figure 5
Antifungal activity of non-volatile constituents of M. suaveolens L.
See this image and copyright information in PMC

References

    1. Shahbazi Y. Application of Carboxymethyl Cellulose and Chitosan Coatings Containing Mentha spicata Essential Oil in Fresh Strawberries. Int. J. Biol. Macromol. 2018;112:264–272. doi: 10.1016/j.ijbiomac.2018.01.186. - DOI - PubMed
    1. Božovic M., Pirolli A., Ragno R. Mentha suaveolens Ehrh. (Lamiaceae) Essential Oil and Its Main Constituent Piperitenone Oxide: Biological Activities and Chemistry. Molecules. 2015;20:8605–8633. doi: 10.3390/molecules20058605. - DOI - PMC - PubMed
    1. Dwivedy A.K., Prakash B., Chanotiya C.S., Bisht D., Dubey N.K. Chemically Characterized Mentha cardiaca L. Essential Oil as Plant Based Preservative in View of Efficacy against Biodeteriorating Fungi of Dry Fruits, Aflatoxin Secretion, Lipid Peroxidation and Safety Profile Assessment. Food Chem. Toxicol. 2017;106:175–184. doi: 10.1016/j.fct.2017.05.043. - DOI - PubMed
    1. El-Kashoury E.S.A., El-Askary H.I., Kandil Z.A., Salem M.A., Sleem A.A. Chemical Composition and Biological Activities of the Essential Oil of Mentha suaveolens Ehrh. Z. Für Naturforsch. C. 2012;67:571–579. doi: 10.1515/znc-2012-11-1207. - DOI - PubMed
    1. El-Sayeda A.E.-K., Hesham I.E.-A., Zeinab A.K., Shahira M.E., Mohamed A.S., Amany A.S. Chemical and Biological Study of Mentha suaveolens Ehrh. Cultivated in Egypt. J. Med. Plants Res. 2014;8:747–755. doi: 10.5897/JMPR2014.5324. - DOI

MeSH terms

LinkOut - more resources