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. 2022 Apr 23;11(9):2369.
doi: 10.3390/jcm11092369.

The Multidimensional Prognostic Index Predicts Mortality in Older Outpatients with Cognitive Decline

Femke C M S Overbeek  1 , Jeannette A Goudzwaard  1 , Judy van Hemmen  2 , Rozemarijn L van Bruchem-Visser  1 , Janne M Papma  2 , Harmke A Polinder-Bos  1 , Francesco U S Mattace-Raso  1
Affiliations

The Multidimensional Prognostic Index Predicts Mortality in Older Outpatients with Cognitive Decline

Femke C M S Overbeek et al. J Clin Med. .

Abstract

Since the heterogeneity of the growing group of older outpatients with cognitive decline, it is challenging to evaluate survival rates in clinical shared decision making. The primary outcome was to determine whether the Multidimensional Prognostic Index (MPI) predicts mortality, whilst assessing the MPI distribution was considered secondary. This retrospective chart review included 311 outpatients aged ≥65 years and diagnosed with dementia or mild cognitive impairment (MCI). The MPI includes several domains of the comprehensive geriatric assessment (CGA). All characteristics and data to calculate the risk score and mortality data were extracted from administrative information in the database of the Alzheimer’s Center and medical records. The study population (mean age 76.8 years, men = 51.4%) was divided as follows: 34.1% belonged to MPI category 1, 52.1% to MPI category 2 and 13.8% to MPI category 3. Patients with dementia have a higher mean MPI risk score than patients with MCI (0.47 vs. 0.32; p < 0.001). The HRs and corresponding 95% CIs for mortality in patients in MPI categories 2 and 3 were 1.67 (0.81−3.45) and 3.80 (1.56−9.24) compared with MPI category 1, respectively. This study shows that the MPI predicts mortality in outpatients with cognitive decline.

Keywords: Multidimensional Prognostic Index; aging; cognitive decline; dementia; frailty; geriatric assessment; mortality.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the study.
Figure 2
Figure 2
Cox regression survival curve stratified by MPI groups. Model adjusted for age and sex.
See this image and copyright information in PMC

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