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. 2022 Apr 24;11(9):2386.
doi: 10.3390/jcm11092386.

The Association between Psychosocial and Age-Related Factors with Adherence to Immunosuppressive Therapies after Renal Transplantation

Justyna Zachciał  1   2 , Izabella Uchmanowicz  2 , Michał Czapla  3   4 , Magdalena Krajewska  1 , Mirosław Banasik  1
Affiliations

The Association between Psychosocial and Age-Related Factors with Adherence to Immunosuppressive Therapies after Renal Transplantation

Justyna Zachciał et al. J Clin Med. .

Abstract

Renal transplantation (RT) is the optimal renal replacement treatment approach in terms of patient survival and high quality of life. Proper adherence to medication is essential in order to prolong graft life and patient survival. This study aimed to investigate the effects of psychosocial factors and age-related declines on adherence in kidney transplant recipients. Methods: This was a cross-sectional study of kidney transplant recipients, based on regression analysis. Patient adherence was assessed with the Basel Assessment of Adherence with Immunosuppressive Medication Scale (BAASIS). Psychosocial and age-related variables were measured with the World Health Organization’s quality of life questionnaire (WHOQoL-BREF), the Mini-Mental State Examination (MMSE), the Hospital Anxiety and Depression Scale (HADS), the Acceptance of Illness Scale (AIS), and the Tilburg Frailty Indicator (TFI). Results: A simple linear regression model indicated that the significant predictors of self-reported adherence (p < 0.05) were age, time since transplant, and anxiety and cognitive functions. For problems with implementing immunosuppressive medication, logistic regression models showed that gender, age, retirement status, hypercholesterolemia, and cognitive impairment were the most significant predictors (p < 0.05). However, after controlling for other predictors in the multiple regression models, anxiety and cognitive ability no longer predicted treatment adherence to immunosuppressive medication. Conclusions: Renal transplantation is the most effective therapy in chronic renal failure patients. Proper adherence to immunosuppressive therapy is critical to prolonging graft and person survival. Our study shows that occupational status more significantly influences adherence to the implementation of treatment in kidney transplant recipients.

Keywords: acceptance of illness; immunosuppressants; kidney transplantation; medication adherence; quality of life.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Neuberger J.M., Bechstein W.O., Kuypers D.R., Burra P., Citterio F., De Geest S., Duvoux C., Jardine A.G., Kamar N., Krämer B.K., et al. Practical Recommendations for Long-term Management of Modifiable Risks in Kidney and Liver Transplant Recipients: A guidance report and clinical checklist by the Consensus on Managing Modifiable Risk in Transplantation (COMMIT) Group. Transplantation. 2017;101:S1–S56. doi: 10.1097/TP.0000000000001651. - DOI - PubMed
    1. Kostalova B., Mala-Ladova K., Kubena A.A., Horne R., Sulkova S.D., Maly J. Changes in Beliefs About Post-Transplant Immunosuppressants over Time and Its Relation to Medication Adherence and Kidney Graft Dysfunction: A Follow-Up Study. Patient Prefer. Adherence. 2021;15:2877–2887. doi: 10.2147/PPA.S344878. - DOI - PMC - PubMed
    1. Dew M.A., DiMartini A.F., Dabbs A.D.V., Myaskovsky L., Steel J., Unruh M., Switzer G.E., Zomak R., Kormos R.L., Greenhouse J.B. Rates and Risk Factors for Nonadherence to the Medical Regimen After Adult Solid Organ Transplantation. Transplantation. 2007;83:858–873. doi: 10.1097/01.tp.0000258599.65257.a6. - DOI - PubMed
    1. Stavrianou K., Pallikarakis N. Quality of life of end-stage renal disease patients and study on the implementation of nocturnal home hemodialysis in Greece. Hemodial. Int. 2007;11:204–209. doi: 10.1111/j.1542-4758.2007.00170.x. - DOI - PubMed
    1. Bohlke M., Marini S.S., Rocha M., Terhorst L., Gomes R.H., Barcellos F.C., Irigoyen M.C.C., Sesso R. Factors associated with health-related quality of life after successful kidney transplantation: A population-based study. Qual. Life Res. 2009;18:1185–1193. doi: 10.1007/s11136-009-9536-5. - DOI - PubMed

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