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Review
. 2022 Apr 25;11(9):2399.
doi: 10.3390/jcm11092399.

Patients with Thyroid Disorder, a Contraindication for Dental Implants? A Systematic Review

Aina Torrejon-Moya  1   2 , Keila Izquierdo-Gómez  1   2 , Mario Pérez-Sayáns  3 , Enric Jané-Salas  1   2 , Antonio Marí Roig  4 , José López-López  1   2
Affiliations
Review

Patients with Thyroid Disorder, a Contraindication for Dental Implants? A Systematic Review

Aina Torrejon-Moya et al. J Clin Med. .

Abstract

The thyroid gland is composed of the thyroid follicles, considered to be the functional units of the thyroid gland. The synthesis of the thyroid hormones occurs in these follicles. Triiodothyronine (T3) and thyroxine (T4) are the thyroid hormones and affect metabolic processes all through the body. This systematic evaluation was performed to answer the following PICO question: "Can patients with thyroid disorders undergo dental implant rehabilitation with the same survival rate as patients without thyroid disorders?". A systematic review of the literature was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements to gather available and current evidence of thyroid disorders and its relationship with dental implants. The electronic search, in the PubMed and Cochrane databases, yielded 22 articles. Out of the 22 articles, only 11 fulfilled the inclusion criteria. Manual research of the reference list yielded no additional papers. According to the SORT criteria and answering our PICO question, level B can be established to conclude that patients with thyroid disorders can be rehabilitated with dental implants, with similar survival rates as patients without thyroid disorders. Papers with higher scientific evidence and bigger sample size should be carried out.

Keywords: dental implants; hyperthyroidism; hypothyroidism; thyroid disorder.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA Flow Diagram.
Figure 2
Figure 2
Risk-of-bias plot.
See this image and copyright information in PMC

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References

    1. Carvalho D.P., Dupuy C. Thyroid hormone biosynthesis and release. Mol. Cell. Endocrinol. 2017;458:6–15. doi: 10.1016/j.mce.2017.01.038. - DOI - PubMed
    1. Harvey C.B., O’Shea P.J., Scott A.J., Robson H., Siebler T., Shalet S.M., Samarut J., Chassande O., Williams G.R. Molecular Mechanisms of Thyroid Hormone Effects on Bone Growth and Function. Mol. Genet. Metab. 2002;75:17–30. doi: 10.1006/mgme.2001.3268. - DOI - PubMed
    1. Delitala A.P., Scuteri A., Doria C. Thyroid Hormone Diseases and Osteoporosis. J. Clin. Med. 2020;9:1034. doi: 10.3390/jcm9041034. - DOI - PMC - PubMed
    1. Szulc P. Biochemical bone turnover markers in hormonal disorders in adults: A narrative review. J. Endocrinol. Investig. 2020;43:1409–1427. doi: 10.1007/s40618-020-01269-7. - DOI - PubMed
    1. Kim S.-M., Ryu V., Miyashita S., Korkmaz F., Lizneva D., Gera S., Latif R., Davies T.F., Iqbal J., Yuen T., et al. Thyrotropin, Hyperthyroidism, and Bone Mass. J. Clin. Endocrinol. Metab. 2021;106:e4809–e4821. doi: 10.1210/clinem/dgab548. - DOI - PMC - PubMed