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. 2022 May 2;11(9):2558.
doi: 10.3390/jcm11092558.

Frequency and Associated Factors of Suicidal Ideation in Patients with Chronic Obstructive Pulmonary Disease

Carlos Roncero  1   2 , Joselín Pérez  3 , Jesús Molina  4 , José Antonio Quintano  5 , Ana Isabel Campuzano  3 , Javier Pérez  1   2 , Marc Miravitlles  6   7
Affiliations

Frequency and Associated Factors of Suicidal Ideation in Patients with Chronic Obstructive Pulmonary Disease

Carlos Roncero et al. J Clin Med. .

Abstract

We aimed to examine the prevalence of suicidal ideation in patients with chronic obstructive pulmonary disease (COPD) and the association between demographic and clinical variables and the occurrence of suicidal thoughts. This was a cross-sectional study. Sociodemographic and clinical data were recorded, and questionnaires were used to assess depressive symptoms (Beck Depression Inventory), comorbidities (Charlson Index), cognitive performance (Mini Mental State Examination), and quality of life (EuroQoL-5 dimensions and CAT). Specific questions about suicide-related behavior were included. Multivariate logistic regression analysis identified the significant factors associated with previous suicidal ideation and suicide attempts. The analysis included 1190 subjects. The prevalence of suicidal ideation and suicide attempts were 12.1% and 2.5%, respectively. Severely depressed patients had the highest prevalence of suicide-related behavior. The adjusted logistic model identified factors significantly associated with suicidal ideation: sex (odds ratio (OR) for women vs. men = 2.722 (95% confidence interval (CI) = 1.771-4.183)), depression score (OR = 1.163 (95% IC = 1.127-1.200)), and Charlson Index (OR 1.228 (95% IC 1.082-1.394)). Suicidal ideation is common in COPD patients, especially in women. While addressing suicidal ideation and suicide prevention, clinicians should first consider the management of depressive symptomatology and the improvement of coping strategies.

Keywords: Beck Depression Inventory; COPD; depression; suicide.

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Conflict of interest statement

Carlos Roncero has received fees to give lectures for Janssen-Cilag, Ferrer-Brainfarma, Pfizer, Indivior, Lundbeck, Otsuka, Servier, GSK, Rovi, Astra, Gilead, MSD, Sanofi, and Exceltis. He has received financial compensation for his participation as a board member of Janssen-Cilag, Lundbeck, Gilead, MSD, Mundipharm, INDIVIOR, Exceltis, and Martindale. He has carried out the PROTEUS project, which was funded by a grant from Reckitt-Benckisert/Indivior. He received two medical education grants by Gilead. Joselín Pérez and Ana Isabel Campuzano are full-time employees of Grupo Ferrer (Barcelona, Spain). José Antonio Quintano received speaker fees from Almirall, Bayer, Boehringuer, Ferrer, GSK, Novartis, Menarini, and TEVA and consulting fees from Almirall, Boehringuer, Ferrer, Menarini, Novartis, and Mundipharma and received registration for medical congresses from Almirall, Pfizer, Gebro, GSK, Mundipharma, Novartis, and ROVI. Jesús Molina has received speaker fees from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Novartis, Mundifarma, and Pfizer and consulting fees from Boehringer Ingelheim, Gebro Pharma, Mundifarma, and GlaxoSmithKline. Javier Pérez has no conflict of interest. Marc Miravitlles has received honoraria from Grupo Ferrer for conducting the DeprEPOC study and has received speaker fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, Menarini, Rovi, Bial, Sandoz, Zambon, CSL Behring, Grifols, and Novartis, consulting fees from AstraZeneca, Atriva Therapeutics, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Bial, Gebro Pharma, CSL Behring, Inhibrx, Laboratorios Esteve, Ferrer, Mereo Biopharma, Verona Pharma, Spin Therapeutics, ONO Pharma, pH Pharma, Palobiofarma SL, Takeda, Novartis, Sanofi, and Grifols and research grants from Grifols.

Figures

Figure 1
Figure 1
Flow diagram for the analysis and sample distribution according to previous suicidal ideation.
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