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. 2022 May 2;11(9):2562.
doi: 10.3390/jcm11092562.

The Association between Gestational Age and Risk for Long Term Ophthalmic Morbidities among Offspring Delivered in Different Preterm Subgroups

Erez Tsumi  1 , Itai Hazan  2 , Tamir Regev  1 , Samuel Leeman  1 , Chiya Barrett  1 , Noa Fried Regev  3 , Eyal Sheiner  4
Affiliations

The Association between Gestational Age and Risk for Long Term Ophthalmic Morbidities among Offspring Delivered in Different Preterm Subgroups

Erez Tsumi et al. J Clin Med. .

Abstract

Objective: To investigate whether there is a linear association between the degree of prematurity and the risk for long-term ophthalmic morbidity among preterm infants. Study design: A population-based, retrospective cohort study, which included all singleton deliveries occurring between 1991 and 2014 at a single tertiary medical center. All infants were divided into four groups according to gestational age categories: extremely preterm births, very preterm births, moderate to late preterm births and term deliveries (reference group). Hospitalizations of offspring up to 18 years of age involving ophthalmic morbidity were evaluated. Survival curves compared cumulative hospitalizations and regression models controlled for confounding variables. Results: During the study period, 243,363 deliveries met the inclusion criteria. Ophthalmic-related hospitalization rates were lower among children born at term (0.9%) as compared with extremely preterm (3.6%), very preterm (2%), and moderate to late preterm (1.4%) born offspring (p < 0.01; using the chi-square test for trends). The survival curve demonstrated significantly different hospitalization rates between the gestational ages (p < 0.001). The regression demonstrated an independent risk for ophthalmic morbidity among extremely preterm born offspring (adjusted hazard ratio 3.8, confidence interval 1.6−9.2, p < 0.01), as well as very preterm and moderate to late preterm (adjusted hazard ratio 2.2 and 1.5, respectively) as compared with term deliveries. Conclusions: The risk for long-term ophthalmic-related hospitalization of preterm offspring gradually decreases as the gestational age increases.

Keywords: gestational age; ophthalmic morbidities; preterm delivery; retinopathy of prematurity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Kaplan-Meier survival curve demonstrating the cumulative incidence of. ophthalmological-related hospitalizations compared to delivery time in weeks.
See this image and copyright information in PMC

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References

    1. Newman D.E., Paamoni-Keren O., Press F., Wiznitzer A., Mazor M., Sheiner E. Neonatal outcome in preterm deliveries between 23 and 27 weeks’ gestation with and without preterm premature rupture of membranes. Arch. Gynecol. Obstet. 2009;280:7–11. doi: 10.1007/s00404-008-0836-8. - DOI - PubMed
    1. Vohr B. Long-term outcomes of moderately preterm, late preterm, and early term infants. Clin. Perinatol. 2013;40:739–751. doi: 10.1016/j.clp.2013.07.006. - DOI - PubMed
    1. Gutvirtz G., Wainstock T., Sheiner E., Pariente G. Prematurity and Long-Term Respiratory Morbidity—What Is the Critical Gestational Age Threshold? J. Clin. Med. 2022;11:751. doi: 10.3390/jcm11030751. - DOI - PMC - PubMed
    1. Davidesko S., Wainstock T., Sheiner E., Pariente G. Long-Term Infectious Morbidity of Premature Infants: Is There a Critical Threshold? J. Clin. Med. 2020;9:3008. doi: 10.3390/jcm9093008. - DOI - PMC - PubMed
    1. Zer S., Wainstock T., Sheiner E., Miodownik S., Pariente G. Identifying the Critical Threshold for Long-Term Pediatric Neurological Hospitalizations of the Offspring in Preterm Delivery. J. Clin. Med. 2021;10:2919. doi: 10.3390/jcm10132919. - DOI - PMC - PubMed

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