ILC Differentiation from Progenitors in the Bone Marrow

Arundhoti Das¹, Christelle Harly^{2

3}, Yi Ding¹, Avinash Bhandoola⁴

Affiliations

¹ T-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
² Université de Nantes, CNRS, INSERM, CRCINA, Nantes, France.
³ LabEx IGO "Immunotherapy, Graft, Oncology", Nantes, France.
⁴ T-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. avinash.bhandoola@nih.gov.

PMID: 35567738
DOI: 10.1007/978-981-16-8387-9_2

Review

ILC Differentiation from Progenitors in the Bone Marrow

Arundhoti Das et al. Adv Exp Med Biol. 2022.

. 2022:1365:7-24.

doi: 10.1007/978-981-16-8387-9_2.

Authors

Arundhoti Das¹, Christelle Harly^{2

3}, Yi Ding¹, Avinash Bhandoola⁴

Affiliations

¹ T-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
² Université de Nantes, CNRS, INSERM, CRCINA, Nantes, France.
³ LabEx IGO "Immunotherapy, Graft, Oncology", Nantes, France.
⁴ T-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. avinash.bhandoola@nih.gov.

PMID: 35567738
DOI: 10.1007/978-981-16-8387-9_2

Abstract

Innate lymphoid cells (ILCs) are a family of immune cells that possess similar functions as T cells. We review steps of central ILC development in the bone marrow of adult mice and discuss recent evidence for peripheral ILC development suggesting extramedullary sites of ILC development. We also assess the contribution of development during different phases of life towards shaping the composition of the adult ILC pool. Finally, we briefly review the local cues that lead to heterogeneity of ILCs between tissues. We propose that tissue-resident ILC progenitors may economically allow tissues to elicit rapid expansion of specific ILC types that are needed based on the nature of antigenic assaults in tissues.

Keywords: Central ILC progenitors; Innate lymphoid cells; Local precursors.

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ILC Differentiation from Progenitors in the Bone Marrow

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ILC Differentiation from Progenitors in the Bone Marrow

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