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Review
. 2022 May 15;39(5):72.
doi: 10.1007/s12032-022-01669-0.

The functions, oncogenic roles, and clinical significance of circular RNAs in renal cell carcinoma

Hui Huang #  1 , Tao Chen #  2 , Fei Li  2 , Dan Jin  1 , Chuan Li  1 , Yongbo Yang  1 , Xuyang Liu  1 , Dongmiao Wang  3 , Jiehui Di  4   5   6
Affiliations
Review

The functions, oncogenic roles, and clinical significance of circular RNAs in renal cell carcinoma

Hui Huang et al. Med Oncol. .

Abstract

Renal cell carcinoma (RCC) is the most common form of malignancy affecting the kidneys. Circular RNAs (circRNAs) are non-coding RNAs that are derived from exonic or intronic sequences through a selective shearing process. There is growing evidence that these circRNAs can influence a range of biological pathways by serving as protein decoys, microRNA sponges, regulators of transcriptional activity, or templates for protein translation. The dysregulation of circRNA expression patterns is a hallmark of RCC and other cancer types, and there is strong evidence that these RNA species can play central roles in the onset and progression of RCC tumors. In the present review, we summarized recent findings on the functional roles and clinical impacts of circRNAs in RCC. Further, we discussed their potential utility as diagnostic biomarkers or targets for therapeutic intervention.

Keywords: Biological function; Renal cell carcinoma; Signaling; Therapeutic targets; circRNA.

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