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. 2022 Sep;35(9):e2976.
doi: 10.1002/jmr.2976. Epub 2022 Jun 4.

Novel Schiff base scaffolds derived from 4-aminoantipyrine and 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde: Synthesis, antibacterial, antioxidant and anti-inflammatory

Mangesh S Kasare  1 , Pratik P Dhavan  2 , Aksh Hina I Shaikh  1 , Bhaskar L Jadhav  2 , Suresh D Pawar  1
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Novel Schiff base scaffolds derived from 4-aminoantipyrine and 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde: Synthesis, antibacterial, antioxidant and anti-inflammatory

Mangesh S Kasare et al. J Mol Recognit. 2022 Sep.

Abstract

The synthesis of four new azo-Schiff base ligands from 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde and 4-aminoantipyrine is described in this study. The molecular structures of all the scaffolds were confirmed using NMR spectroscopies such as 1 H and 13 C, as well as FT-IR and Mass spectroscopy. After successful synthesis and characterization of all the ligands, their in vitro antibacterial, antioxidant and anti-inflammatory activities were carried out by using standard protocols. Results revealed that all the four ligands (L1-L4) possessed excellent biological potency.

Keywords: 4-aminoantipyrine; anti-inflammatory; antibacterial; antioxidant; azo-Schiff base.

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References

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