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. 2022 Oct;103(10):2001-2008.
doi: 10.1016/j.apmr.2022.04.009. Epub 2022 May 13.

Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Nermine Abdelwahab  1 , Nicholas E Ingraham  2 , Nguyen Nguyen  3 , Lianne Siegel  4 , Greg Silverman  5 , Himanshu Shekhar Sahoo  6 , Serguei Pakhomov  7 , Leslie R Morse  3 , Joanne Billings  2 , Michael G Usher  8 , Tanya E Melnik  8 , Christopher J Tignanelli  9 , Farha Ikramuddin  3
Affiliations

Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Nermine Abdelwahab et al. Arch Phys Med Rehabil. 2022 Oct.

Abstract

Objective: To examine the frequency of postacute sequelae of SARS-CoV-2 (PASC) and the factors associated with rehabilitation utilization in a large adult population with PASC.

Design: Retrospective study.

Setting: Midwest hospital health system.

Participants: 19,792 patients with COVID-19 from March 10, 2020, to January 17, 2021.

Intervention: Not applicable.

Main outcome measures: Descriptive analyses were conducted across the entire cohort along with an adult subgroup analysis. A logistic regression was performed to assess factors associated with PASC development and rehabilitation utilization.

Results: In an analysis of 19,792 patients, the frequency of PASC was 42.8% in the adult population. Patients with PASC compared with those without had a higher utilization of rehabilitation services (8.6% vs 3.8%, P<.001). Risk factors for rehabilitation utilization in patients with PASC included younger age (odds ratio [OR], 0.99; 95% confidence interval [CI], 0.98-1.00; P=.01). In addition to several comorbidities and demographics factors, risk factors for rehabilitation utilization solely in the inpatient population included male sex (OR, 1.24; 95% CI, 1.02-1.50; P=.03) with patients on angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers 3 months prior to COVID-19 infections having a decreased risk of needing rehabilitation (OR, 0.80; 95% CI, 0.64-0.99; P=.04).

Conclusions: Patients with PASC had higher rehabilitation utilization. We identified several clinical and demographic factors associated with the development of PASC and rehabilitation utilization.

Keywords: COVID-19; Function; Rehabilitation.

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Figures

Fig 1
Fig 1
Study diagram of patients included in final analysis of COVID-19 data registry. Abbreviation: PCR, polymerase chain reaction.
See this image and copyright information in PMC

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