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. 2022 Aug 1:69:128783.
doi: 10.1016/j.bmcl.2022.128783. Epub 2022 May 13.

2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists

Shouming Wang  1 , Anssi Haikarainen  2 , Antti Pohjakallio  2 , Julius Sipilä  2 , Janne Kaskinoro  3 , Satu Juhila  3 , Niina Jalava  4 , Mikko Koskinen  3 , Marja Vesajoki  5 , Esa Kumpulainen  2 , Jarmo Pystynen  2 , Tuula Koskelainen  2 , Patrik Holm  2 , David Din Belle  2
Affiliations

2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists

Shouming Wang et al. Bioorg Med Chem Lett. .

Abstract

In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.

Keywords: Benzodioxine; Piperidine; α2 adrenoceptors; α2c Antagonist.

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