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Case Reports
. 2022 Dec 15;61(24):3709-3712.
doi: 10.2169/internalmedicine.9747-22. Epub 2022 May 14.

Sansoninto-induced Lung Injury

Kosaku Komiya  1   2 , Marcelo Takahiro Mitsui  3 , Toru Watanabe  3 , Masaru Nasu  2 , Kazufumi Hiramatsu  1 , Jun-Ichi Kadota  1
Affiliations
Case Reports

Sansoninto-induced Lung Injury

Kosaku Komiya et al. Intern Med. .

Abstract

A man in his 70s visited our department for dyspnea with pulmonary infiltrate that was unresolved by antibiotics. He had been taking Sansoninto for five years and doubled its dose a month ago. After discontinuing Sansoninto without any additional medications, his symptoms gradually disappeared, and pulmonary infiltration improved. Drug lymphocyte stimulation tests showed a positive result for Sansoninto. We diagnosed this patient with Sansoninto-induced lung injury. Sansoninto is a combination drug that consists of sansonin, bukuryo, senkyo, chimo, and kanzo. This paper reports the first case of Sansoninto-induced lung injury and discusses the mechanism considering its components.

Keywords: Chinese herb; Sansoninto; drug-induced pneumonitis; kampo.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure 1.
Figure 1.
Chest X-ray features at the first visit to our department (A) and 1 month (B) and 6 months (C) after Sansoninto was withdrawn.
Figure 2.
Figure 2.
Chest computed tomography features at the first visit to our department (A-C) and 6 months (D-F) after Sansoninto was withdrawn.
See this image and copyright information in PMC

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