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Review
. 2022 Aug;279(8):3811-3820.
doi: 10.1007/s00405-022-07382-y. Epub 2022 May 15.

Effect of sleep surgery on lipid profiles in adults with obstructive sleep apnea: a meta-analysis

Chia-Hsuan Lee  1   2 , Wei-Chung Hsu  3   4   5 , Te-Huei Yeh  3   4   5 , Jenq-Yuh Ko  3   4 , Ming-Tzer Lin  6   7 , Kun-Tai Kang  8   9   10
Affiliations
Review

Effect of sleep surgery on lipid profiles in adults with obstructive sleep apnea: a meta-analysis

Chia-Hsuan Lee et al. Eur Arch Otorhinolaryngol. 2022 Aug.

Abstract

Purpose: The effects of sleep surgery on the lipid profile of adults diagnosed as having obstructive sleep apnea (OSA) remain unclear. This meta-analysis aimed to clarify whether sleep surgeries improve patients' lipid profile.

Methods: The study protocol was registered on PROSPERO (CRD42020154425). Two authors independently searched the PubMed, MEDLINE, EMBASE, and Cochrane review databases up to September 2020 using keywords such as sleep apnea, OSA, sleep apnea syndromes, lipids, and surgery. The effects of sleep surgery on the apnea-hypopnea index (AHI) and lipid profile parameters were evaluated using a random-effects model.

Results: Thirteen studies were included, with a total of 710 patients (mean age: 42.0 years; 85% men; mean sample size: 54.6 patients). The summary estimate of AHI change was - 20.6 events/h (95% CI - 25.9 to - 15.3) and the Epworth Sleepiness Scale score was - 4.2 (95% CI - 5.9 to - 2.5). Sleep surgery lowered total cholesterol (mean - 7.7 mg/dL; 95% CI - 12.2 to - 3.2), low-density lipoprotein (mean - 7.2 mg/dL; 95% CI - 11.0 to - 3.3), and triglyceride (mean - 14.0 mg/dL; 95% CI - 22.2 to - 5.8) levels but did not affect high-density lipoprotein (mean 1.5 mg/dL; 95% CI - 0.6 to 3.7) levels. Subgroup analysis revealed that the lipid profile changes were not associated with the surgical procedure but with the degree of OSA improvement. Meta-regression analyses demonstrated that the improvement in the lipid profile was positively correlated with AHI reduction.

Conclusion: Surgeries for OSA may improve the lipid profile, which is positively correlated with the degree of OSA improvement.

Keywords: Adult; Lipids; Meta-analysis; Sleep apnea syndromes; Surgery; Uvulopalatopharyngoplasty.

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Comment in

  • Laryngopharyngeal reflux and insomnia.
    Huang GJ, Li SH, Long CQ, Fan ZJ. Huang GJ, et al. Eur Arch Otorhinolaryngol. 2022 Jul;279(7):3749-3750. doi: 10.1007/s00405-022-07337-3. Epub 2022 Mar 9. Eur Arch Otorhinolaryngol. 2022. PMID: 35266027 No abstract available.

References

    1. Gottlieb DJ, Punjabi NM (2020) Diagnosis and management of obstructive sleep apnea: a review. JAMA 323(14):1389–1400. https://doi.org/10.1001/jama.2020.3514 - DOI - PubMed
    1. Heinzer R, Vat S, Marques-Vidal P, Marti-Soler H et al (2015) Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med 3(4):310–318. https://doi.org/10.1016/S2213-2600(15)00043-0 - DOI - PubMed - PMC
    1. Schwartz AR, Patil SP, Laffan AM, Polotsky V, Schneider H, Smith PL (2008) Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches. Proc Am Thorac Soc 5(2):185–192. https://doi.org/10.1513/pats.200708-137MG - DOI - PubMed - PMC
    1. Xu S, Wan Y, Xu M et al (2015) The association between obstructive sleep apnea and metabolic syndrome: a systematic review and meta-analysis. BMC Pulm Med 15:105. https://doi.org/10.1186/s12890-015-0102-3 - DOI - PubMed - PMC
    1. Nadeem R, Singh M, Nida M et al (2014) Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. J Clin Sleep Med 10(5):475–489. https://doi.org/10.5664/jcsm.3690 - DOI - PubMed - PMC

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