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. 2022 Jun;32(3):209-212.
doi: 10.1007/s10286-022-00867-0. Epub 2022 May 16.

A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS

Mitchell G Miglis  1 , Jordan Seliger  2 , Ruba Shaik  2 , Christopher H Gibbons  3
Affiliations

A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS

Mitchell G Miglis et al. Clin Auton Res. 2022 Jun.
No abstract available

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Conflict of interest statement

M. G. Miglis reports grant funding from Dysautonomia International, serves on the medical advisory board of Dysautonomia International (unpaid), and reports personal compensation for consulting work with MED-IQ, 2nd MD, and Infinite MD. C. Gibbons has served as a scientific advisor for CND Life Sciences, has stock options with CND Life Sciences, and has received personal compensation for his editorial activities (Associate Editor) with Autonomic Neuroscience Basic and Clinical. R. Shaik and J. Seliger report nothing to disclose.

Figures

Fig. 1
Fig. 1
Examples of nerve fibers from two patients (A–C and D–F). On the left (A and D), nerve fibers surrounding a blood vessel are shown in green through immunostaining with protein gene product 9.5 (PGP9.5). In B and E, the presence of phosphorylated α-synuclein (P-SYN) is seen in red. In C and F, the merged image reveals the presence of intra-axonal phosphorylated α-synuclein in orange
See this image and copyright information in PMC

References

    1. Larsen NW, Stiles LE, Miglis MG. Preparing for the long-haul: autonomic complications of COVID-19. Auton Neurosci. 2021;235:102841. doi: 10.1016/j.autneu.2021.102841. - DOI - PMC - PubMed
    1. Abrams RMC, Simpson DM, Navis A, et al. Small fiber neuropathy associated with SARS-CoV-2 infection. Muscle Nerve. 2021 doi: 10.1002/MUS.27458. - DOI - PMC - PubMed
    1. Wang N, Garcia J, Freeman R, Gibbons CH. Phosphorylated alpha-synuclein within cutaneous autonomic nerves of patients with Parkinson’s disease: the implications of sample thickness on results. J Histochem Cytochem. 2020;68:669–678. doi: 10.1369/0022155420960250. - DOI - PMC - PubMed
    1. Provitera V, Gibbons CH, Wendelschafer-Crabb G, et al. A multi-center, multinational age- and gender-adjusted normative dataset for immunofluorescent intraepidermal nerve fiber density at the distal leg. Eur J Neurol. 2016;23:333–338. doi: 10.1111/ene.12842. - DOI - PubMed
    1. Merello M, Bhatia KP, Obeso JA. SARS-CoV-2 and the risk of Parkinson’s disease: facts and fantasy. Lancet Neurol. 2021;20:94. doi: 10.1016/S1474-4422(20)30442-7. - DOI - PMC - PubMed

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