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Observational Study
. 2022 May 15;21(1):44.
doi: 10.1186/s12944-022-01655-5.

Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults

Maobin Kuang #  1 , Nan Peng #  1 , Jiajun Qiu #  1 , Yanjia Zhong  2 , Yang Zou  3 , Guotai Sheng  4
Affiliations
Observational Study

Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults

Maobin Kuang et al. Lipids Health Dis. .

Abstract

Background: Low-density lipoprotein:high-density lipoprotein cholesterol ratio (LDL:HDL ratio) has a good performance in identifying diabetes mellitus (DM) and insulin resistance. However, it is not yet clear whether the LDL:HDL ratio is associated with a high-risk state of prediabetes.

Methods: This cohort study retrospectively analyzed the data of 100,309 Chinese adults with normoglycemia at baseline. The outcome event of interest was new-onset prediabetes. Using multivariate Cox regression and smoothing splines to assess the association of LDL:HDL ratio with prediabetes.

Results: During an average observation period of 37.4 months, 12,352 (12.31%) subjects were newly diagnosed with prediabetes. After adequate adjustment for important risk factors, the LDL:HDL ratio was positively correlated with the prediabetes risk, and the sensitivity analysis further suggested the robustness of the results. Additionally, in stratified analysis, we discovered significant interactions between LDL:HDL ratio and family history of DM, sex, body mass index and age (all P-interaction < 0.05); among them, the LDL:HDL ratio-related prediabetes risk decreased with the growth of body mass index and age, and increased significantly in women and people with a family history of DM.

Conclusions: The increased LDL:HDL ratio in the Chinese population indicates an increased risk of developing prediabetes, especially in women, those with a family history of DM, younger adults, and non-obese individuals.

Keywords: Chinese adults; LDL:HDL ratio; Longitudinal cohort; Prediabetes.

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Conflict of interest statement

The author reports no conflicts of interest in this work.

Figures

Fig. 1
Fig. 1
Flow diagram of subjects included in the cohort study
Fig. 2
Fig. 2
Kaplan-Meier analysis of future prediabetes risk according to LDL:HDL ratio quartiles. LDL:HDL ratio: low-density lipoprotein:high-density lipoprotein cholesterol ratio
Fig. 3
Fig. 3
Hazard ratios (95% confidence intervals) for the non-linear relationship between LDL:HDL ratio and the risk of prediabetes. LDL:HDL ratio: low-density lipoprotein:high-density lipoprotein cholesterol ratio
See this image and copyright information in PMC

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