Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Nov;64(2):250-3.
doi: 10.1016/0016-6480(86)90010-9.

Calcium-dependent chronotropic action of bovine parathyroid hormone (1-34) in isolated atria of Japanese quail, Coturnix coturnix japonica

J S Sham, P K Pang

Calcium-dependent chronotropic action of bovine parathyroid hormone (1-34) in isolated atria of Japanese quail, Coturnix coturnix japonica

J S Sham et al. Gen Comp Endocrinol. 1986 Nov.

Abstract

The involvement of extracellular calcium in the chronotropic action of parathyroid hormone (PTH) in isolated quail atria was studied. Bovine (b) PTH-(1-34) caused dose-dependent increases in the atrial beating rate. The PTH-induced positive chronotropism was significantly attenuated by lowering the extracellular calcium concentration or by using the calcium channel antagonists verapamil and D600. This suggests the importance of calcium influx in the cardiac action of PTH. beta-Adrenergic blockade with propranolol did not affect the responses to bPTH-(1-34). This further substantiates the previous findings that the PTH action is independent of cardiac beta-adrenoceptor stimulation.

PubMed Disclaimer

Publication types