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. 1986;48(1):65-70.
doi: 10.1016/0378-1119(86)90352-5.

Characterization of a human orphon 28 S ribosomal DNA

J Munro, R H Burdon, D P Leader

Characterization of a human orphon 28 S ribosomal DNA

J Munro et al. Gene. 1986.

Abstract

We have isolated clones in which two regions of the human genome are represented, each containing an orphon: a dispersed copy of 28S rDNA. Nucleotide (nt) sequence analysis established that one of these, H28S-O1, corresponds to nt 3627-4105 of human 28S rDNA, but in a mutated form. The orphon was flanked on one side by a portion of the L1Hs long interspersed repeat family of the human genome. Although H25S-O1 is not flanked by the terminal direct repeats characteristic of transposed DNA, it is possible that it is a processed pseudogene.

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