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. 2022 May 4:22:63-66.
doi: 10.1016/j.phro.2022.04.010. eCollection 2022 Apr.

Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas

Egor Borzov  1 , Raquel Bar-Deroma  1 , Myroslav Lutsyk  1
Affiliations

Physical aspects of a spatially fractionated radiotherapy technique for large soft tissue sarcomas

Egor Borzov et al. Phys Imaging Radiat Oncol. .

Abstract

This work demonstrates the safety and feasibility of Lattice Radiotherapy (LRT) for large soft tissue sarcoma in neoadjuvant radiotherapy. The treatment consisted of two courses: the LRT course with a single fraction of 20 Gy delivered to high dose nuclei (HDN) regions and the conventional course with 25 fractions of 2 Gy delivered to the planning target volume. HDN shaped as cylinders with a 1 cm diameter and 1 cm height were placed within the gross tumour volume. The number of HDNs and their position were determined based on tumor size and proximity to organs at risk. Three patients were irradiated using the LRT technique.

Keywords: GRID; LRT; SFRT; Soft tissue sarcoma.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Illustration of dose (A) and HDN spatial (B) distributions inside leg sarcoma. (A): Isolines legend: brown – 24 Gy, red – 20 Gy, green – 17 Gy, blue – 7 Gy. (B): HDNs (red) are inside GTV (green) that contoured based on MRI and planning CT. CTV (yellow) and PTV (outer red) are used for a treatment of 50 Gy in 25 fractions. OARs: nerve (blue), femur (purple), skin (blue, contralateral leg (light yellow), and avoidance structure for lymphatic drainage (orange) are contoured. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
See this image and copyright information in PMC

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