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. 2022 May 6:14:193-202.
doi: 10.2147/RRU.S359715. eCollection 2022.

The Correlation Between Platelet Count and Survival in Prostate Cancer

Tünde Mezei  1 , Imre Bőde  1 , Péter Tenke  1 , Valéria Jósa  2 , Keresztély Merkel  3 , Zsuzsanna Szilasi  4 , Attila Tordai  5 , Domokos Máthé  6 , Zsolt Baranyai  7
Affiliations

The Correlation Between Platelet Count and Survival in Prostate Cancer

Tünde Mezei et al. Res Rep Urol. .

Abstract

Purpose: A number of studies have confirmed that elevated platelet count accompanying various solid tumours is associated with worse survival. However, only meagre data are available on the relationship between thrombocytosis and survival in prostate cancer.

Methods: We conducted a retrospective analysis on clinical-pathological data accumulated from 316 patients during on average 51 months of follow-up after laparoscopic prostatectomy performed for prostate cancer. We analyzed the relationship between platelet count, risk factors, prostate-specific antigen (PSA) and cancer stage with use the Tumor, Node, Metastase system (TNM), as well as surgical margin, and prognosis.

Results: Thrombocytosis occurred in only one out of the 316 patients. The multivariate Cox proportional hazard model showed that preoperative PSA, risk group, preoperative haemoglobin level, and surgical margin status were significant, independent predictors of biochemical progression-free survival. By contrast, age at diagnosis and thrombocytosis had no such predictive value.

Conclusion: We could not demonstrate an association between elevated platelet count and worse survival in our study population of patients with prostate cancer.

Keywords: pathomechanism; prognosis; prostate cancer; solid tumor; thrombocytosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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