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Review
. 2022 Apr 29:13:874388.
doi: 10.3389/fneur.2022.874388. eCollection 2022.

Cerebellar and/or Brainstem Lesions Indicate Poor Prognosis in Multiple Sclerosis: A Systematic Review

Yuyuan Yang  1 , Meng Wang  1 , Lulu Xu  1 , Meixiang Zhong  1 , Yajuan Wang  2 , Moxin Luan  1 , Xingao Li  1 , Xueping Zheng  1
Affiliations
Review

Cerebellar and/or Brainstem Lesions Indicate Poor Prognosis in Multiple Sclerosis: A Systematic Review

Yuyuan Yang et al. Front Neurol. .

Abstract

Multiple sclerosis is a serious neurological disease that affects millions of people worldwide. Cerebellar and brainstem symptoms are common in the course of multiple sclerosis, but their prognostic value is unclear. This systematic review aimed to determine the relationship between the location of lesions in the cerebellum and/or brainstem and the prognosis in multiple sclerosis. In this systematic review, we searched and comprehensively read articles related to this research topic in Chinese and English electronic databases (PubMed, Embase, Cochrane Library, CNKI, and CBM) using search terms "multiple sclerosis," "cerebellum," "brainstem," "prognosis," and others. Cerebellar and brainstem clinically isolated syndromes and clinically definite multiple sclerosis were important predictors of transformation (hazard ratio, 2.58; 95% confidence interval, 1.58-4.22). Cerebellar and/or brainstem lesions indicate a poor overall prognosis in multiple sclerosis, but because of inconsistency, more clinical data are needed.

Keywords: brainstem; cerebellum; disability outcome; multiple sclerosis; predictors.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-analyses.
Figure 2
Figure 2
Brainstem and cerebellar lesions predict the risk ratio of conversion of clinically isolated syndromes to clinically definite multiple sclerosis. HR, hazards ratio; CI, confidence interval.
See this image and copyright information in PMC

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