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Case Reports
. 2022 May 11:10:2050313X221097770.
doi: 10.1177/2050313X221097770. eCollection 2022.

Histological study of eyelid hidrocystoma: A clinical case

Sofia Karachrysafi  1   2 , Georgios Fadel  1 , Viktoria Kapourani  1 , Fani Akritidou  2 , Pinelopi Anastasiadou  3 , Theodora Papamitsou  2 , Antonia Sioga  2 , Elie Fadel  1
Affiliations
Case Reports

Histological study of eyelid hidrocystoma: A clinical case

Sofia Karachrysafi et al. SAGE Open Med Case Rep. .

Abstract

Hidrocystomas are benign lesions with frequent localization on the eyelids and common appearance as isolated translucent cystic lesions. The multiple and bilateral localization has been associated with systemic diseases or epidermodysplasia. The histological and ultrastructural study contributes to the distinction in eccrine or apocrine. In this clinical case, multiple bilateral skin lesions of the eyelids were removed surgically from a 55-year-old male patient with free medical history. The lesions were fully removed surgically without rupture of the cysts. The obtained tissues were fixed and prepared for an anatomical pathology study as well as observation under the electron microscope. The histological study revealed cystic lesions with low cuboid epithelium and presence of cells and collagen fibrils, while the ultrastructural study also revealed the presence of apoptotic and secretory cells as well as vacuolization of the cytoplasm. No relapse of the lesions was obtained. In conclusion, the histological and ultrastructural study of multiple hidrocystomas can highlight special features that help to better classify and diagnose eccrine or apocrine hidrocystomas, while surgical removal without rupture of the cyst can prevent reappearance.

Keywords: Hidrocystomas; benign lesions; eyelid; histological study; ultrastructural study.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Multiple bilateral skin lesions of the eyelids before the surgical excision.
Figure 2.
Figure 2.
Multiple bilateral skin lesions of the eyelids after the surgical excision.
Figure 3.
Figure 3.
Cells inside the cyst (*). Simple cuboidal epithelium on the cyst’s wall (↑). Stratified columnar conjunctival epithelium (*). EH×40.
Figure 4.
Figure 4.
Cells and fibrils within the cyst (*). Simple cuboidal epithelium on the cyst’s wall (↑). Stratified columnar conjunctival epithelium (*). EH×160.
Figure 5.
Figure 5.
Cells and fibrils within the cyst (*). Vacuolization in the intercellular space (↑). EH×400.
Figure 6.
Figure 6.
Cell nucleus showing condensation of chromatin (N). Vacuoles inside the cytoplasm (↑). Collagen fibrils (*). Fine granular cytoplasmic material (*). Vacuolization in the intercellular space (↑).
Figure 7.
Figure 7.
Cell nucleus in apoptosis (N). Collagen fibrils (*). Fine granular cytoplasmic material (*). Vacuolization in the intercellular space (↑). Presence of bacteria (↑).
Figure 8.
Figure 8.
Cell with secretory characteristics (C). Cell nucleus in apoptosis (N). Vacuoles inside the cytoplasm (↑). Collagen fibrils (*). Fine granular cytoplasmic material (*). Vacuolization in the intercellular space (↑). Presence of bacteria (↑).
See this image and copyright information in PMC

References

    1. Geist CE, Zamani M. Benign epithelial tumors. In: Albert DM, Miller JW. (eds) Albert and Jakobiec’s principles and practice of ophthalmology. Philadelphia, PA: Saunders/Elsevier, 2008, pp. 3243–3245.
    1. Deprez M, Uffer S. Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature. Am J Dermatopathol 2009; 31(3): 256–262. - PubMed
    1. Alfadley A, Al Aboud K, Tulba A, et al. Multiple eccrine hidrocystomas of the face. Int J Dermatol 2001; 40(2): 125–129. - PubMed
    1. Kaur C, Sarkar R, Kanwar AJ, et al. Multiple eccrine hidrocystomas. J Eur Acad Dermatol Venereol 2002; 16(3): 288–290. - PubMed
    1. Yasaka N, Iozumi K, Nashiro K, et al. Bilateral periorbital eccrine hidrocystoma. J Dermatol 1994; 21(7): 490–493. - PubMed

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