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. 2022 Apr-Jun;13(2):114-117.
doi: 10.4103/picr.picr_55_22. Epub 2022 Apr 6.

Equivalence trials

Priya Ranganathan  1 , C S Pramesh  2 , Rakesh Aggarwal  3
Affiliations

Equivalence trials

Priya Ranganathan et al. Perspect Clin Res. 2022 Apr-Jun.

Abstract

In an equivalence trial, researchers aim to show that a new intervention is more or less similar to an existing standard of care, i.e., the two are "equivalent". In this article, we discuss some aspects of the design, analysis, interpretation and reporting of equivalence trials.

Keywords: Randomized Controlled Trials as Topic; Research Methodology; Research design.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Null and alternate hypotheses in an equivalence trial
Figure 2
Figure 2
Interpretation of results of an equivalence trial
Figure 3
Figure 3
Negative results in superiority trials do not imply equivalence
See this image and copyright information in PMC

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