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. 2022 Apr 29:12:879889.
doi: 10.3389/fonc.2022.879889. eCollection 2022.

Comparison of Laparoscopic and Open Surgery for Women With Early-Stage Epithelial Ovarian Cancer

Xuting Ran  1   2 , Xinlin He  1   2 , Zhengyu Li  1   2
Affiliations

Comparison of Laparoscopic and Open Surgery for Women With Early-Stage Epithelial Ovarian Cancer

Xuting Ran et al. Front Oncol. .

Abstract

Objective: This study evaluated the oncologic outcomes of laparoscopy and laparotomy in the management of early-stage ovarian cancer patients.

Methods: We conducted an observational study of women diagnosed with International Federation of Gynecology and Obstetrics (FIGO) 2014 stage I ovarian cancer who underwent surgery at the West China Second University Hospital from 2012 to 2020. Patients who received adjuvant chemotherapy before surgery, those with non-epithelial histopathological types, or those with insufficient data were excluded. Using propensity score matching, data from consecutive laparoscopic patients treated by laparoscopy were matched 1:2 with a cohort of patients undergoing open surgery. The operative and survival outcomes among the matched cohorts were examined using the Kaplan-Meier method.

Results: Among 200 eligible patients, 74 patients undergoing laparoscopy were compared with a cohort of 126 patients undergoing open surgery. Baseline characteristics were similar between groups after matching. Patients who had laparoscopy had a shorter operative time (P = 0.001), a shorter hospital stay (P <0.001), and lower blood loss (P = 0.001) than patients who had open surgery. The median (range) follow-up period was 43.0 (38.8-47.2) and 45.0 (36.0-54.0) months for cases and controls, respectively (P <0.001). There are no significant differences in progression-free survival (P = 0.430, log-rank test) and overall survival (P = 0.067, log-rank test) between the two groups.

Conclusions: There is no difference in prognosis between laparoscopic and open surgery in women with stage I epithelial ovarian cancer. Laparoscopic treatment of early-stage ovarian cancer is safe and feasible for stage I epithelial ovarian cancer patients.

Keywords: early-stage ovarian cancer; laparoscopy; laparotomy; staging; survival.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of patients’ selection.
Figure 2
Figure 2
Overall survival of laparoscopy and laparotomy in patients with early EOC.
Figure 3
Figure 3
Progression-free survival of laparoscopy and laparotomy in patients with early EOC.
See this image and copyright information in PMC

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