Case Report: Magnetic Resonance Imaging Features of Scrotal Angiomyofibroblastoma (AMF) With Pathologic Correlation

Abstract

Angiomyofibroblastoma (AMF) is a rare benign myofibroblastic tumor that mainly occurs in the genital tract of middle-aged female patients. However, it can also arise in the scrotum, spermatic cord, and bladder. We described, herein, a case of a 42-year-old patient who was admitted to our hospital with a left scrotal mass. Imaging examinations showed that the mass had abundant vessels and displayed obvious progressive intensification on enhanced MRI. The following histopathological and immunohistochemical studies led to the diagnosis of AMF. Here, we describe the magnetic resonance imaging findings of a case of scrotal AMF. We hope that the information can help radiologists to identify AMF.

Keywords: aggressive angiomyxoma; angiomyofibroblastoma (AMF); angiomyofibroblastoma-like tumor; case report; magnetic resonance imaging.

Figure 1

A 42-year-old man with AMF. On T1-weighted images, the tumor reveals low signal intensity but high signal intensity in some circuitous strips (A). On coronal fat-saturated T2-weighted images and sagittal T2-weighted images, the tumor is well-marginated with high inhomogeneous signal intensity (B,C). DWI shows a low-signal tumor (D). The images of contrast-enhanced MRI show a heterogeneous and distinctly enhanced mass. As time goes on, the enhancement of the tumor is more obvious (E,F).

Figure 2

Hematoxylin-eosin (HE) staining and immunohistochemistry of the tumor. Thin-walled blood vessels surrounded by several spindle cells can be seen in the images (A,B). Image A and Image B represent 50× and 100×, respectively. The desmin is positive in immunohistochemistry (C).