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. 1987;25(3):167-70.
doi: 10.1007/BF00344030.

Statement on the nomenclature of dog C4 allotypes

G Doxiadis, W Schoen, I Doxiadis, H J Deeg, G J O'Neill, H Grosse-Wilde

Statement on the nomenclature of dog C4 allotypes

G Doxiadis et al. Immunogenetics. 1987.

Abstract

As a collaborative work of three laboratories the polymorphism of the canine fourth complement component (C4) was studied in a total of 131 unrelated dogs from different breeds and mongrels. Using high voltage electrophoresis followed by an immunoblotting technique, we detected eight distinct variants. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of canine C4 showed an additional heterogeneity of the alpha and gamma chains which resulted in a total of 11 variants in the population studied. So that more precise information concerning the respective C4 allotypes will be available, a nomenclature is proposed designating not only the migration pattern of the C4 variants in agarose gels but also the heterogeneity of the C4 chains observed in SDS-PAGE.

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