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. 2022:1377:119-127.
doi: 10.1007/978-981-19-1592-5_9.

HDL and Diabetes

Blake J Cochran  1 , Bikash Manandhar  1 , Kerry-Anne Rye  2
Affiliations

HDL and Diabetes

Blake J Cochran et al. Adv Exp Med Biol. 2022.

Abstract

Diabetes is a worldwide public health issue, with the number of cases expected to reach 642 million by 2040. Patients with diabetes are at a two- to four-fold increased risk of developing cardiovascular disease. This chapter focuses on the anti-diabetic and cardioprotective functions of plasma high-density lipoproteins (HDLs). HDLs and the main HDL apolipoprotein, apoA-I, improves pancreatic beta cell function. ApoA-I also improves insulin sensitivity. The development of novel, bifunctional HDL-based interventions are a promising therapeutic option for the treatment of cardiometabolic diseases.

Keywords: Antidiabetic; Diabetes; Insulin sensitivity; β cell.

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