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. 2022 Jun:194:50-53.
doi: 10.1016/j.jcpa.2022.03.010. Epub 2022 Apr 27.

Subungual Pigmented Squamous Cell Carcinoma in a Dog

Yeseul Yang  1 , Du-Min Go  2 , Jae-Ha Jung  3 , Dansong Seo  1 , Sung-Hyun Hwang  1 , Mijung Lee  4 , Dae-Yong Kim  5 , Yongbaek Kim  6
Affiliations

Subungual Pigmented Squamous Cell Carcinoma in a Dog

Yeseul Yang et al. J Comp Pathol. 2022 Jun.

Abstract

An 11-year-old spayed female Miniature Schnauzer dog was presented with loss of a claw caused by a nail bed mass. Histopathological evaluation revealed that the mass comprised neoplastic squamous cells with abundant cytoplasmic melanin pigment. Immunohistochemically, the neoplastic cells were positive for cytokeratin and negative for vimentin and ionized calcium-binding adaptor molecule 1, supporting a diagnosis of pigmented squamous cell carcinoma. To our knowledge, this is the first report of subungual pigmented squamous cell carcinoma in animals.

Keywords: dog; melanin; pigment; squamous cell carcinoma; subungual.

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