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Review
. 2022 Jun;36(3):507-520.
doi: 10.1016/j.hoc.2022.02.006. Epub 2022 May 13.

New Insights into Adjuvant Therapy for Localized Colon Cancer

Nadia Saoudi González  1 , Francisco Javier Ros Montaña  2 , David García Illescas  1 , Iosune Baraibar Argota  1 , Francesc Salvà Ballabrera  1 , Ma Elena Élez Fernández  3
Affiliations
Review

New Insights into Adjuvant Therapy for Localized Colon Cancer

Nadia Saoudi González et al. Hematol Oncol Clin North Am. 2022 Jun.

Abstract

Currently, clinicopathologic characteristics of colon cancer tumors guide the selection of patients suitable for adjuvant therapy. Circulating tumor DNA (ctDNA) analysis after surgery has a strong correlation with prognosis, and positive ctDNA status defines a subset of patients with high risk of recurrence. Ongoing interventional adjuvant trials in colon cancer including ctDNA analyses will determine the predictive value of ctDNA in the adjuvant setting. For patients with stage III colon cancer, noninferiority of 3 months of adjuvant therapy compared with 6 months has not been demonstrated. However, for selected subgroups, the shorter duration of therapy may limit toxic effects without impairing clinical outcomes.

Keywords: Adjuvant treatment; Colon cancer; Immunoscore; ctDNA; liquid biopsy.

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Conflict of interest statement

Disclosure The authors have no COI in relation to this review.

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