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. 2022 Jul;49(8):2504-2513.
doi: 10.1007/s00259-022-05838-1. Epub 2022 May 17.

Ultrafast 30-s total-body PET/CT scan: a preliminary study

Yiqiu Zhang #  1   2   3 , Pengcheng Hu #  1   2   3 , Yibo He  1   2   3 , Haojun Yu  1   2   3 , Hui Tan  1   2   3 , Guobing Liu  1   2   3 , Jianying Gu  4 , Hongcheng Shi  5   6   7
Affiliations

Ultrafast 30-s total-body PET/CT scan: a preliminary study

Yiqiu Zhang et al. Eur J Nucl Med Mol Imaging. 2022 Jul.

Abstract

Purpose: The aim of this study is to explore the diagnostic value of the images obtained in ultrafast 30-s acquisition time by the total-body PET/CT (18F-FDG injection dose of about 3.7 MBq/kg), and to evaluate whether they can meet the requirements of clinical diagnosis or not.

Methods: This retrospective study explored the clinical value of ultrafast 30-s 18F-FDG total-body PET/CT in 88 oncology patients, using the post-surgical pathological diagnosis as the reference standard. The data were acquired over 300 s and reconstructed using all 300-s data (G300) and only the initial 30 s (G30). Two readers independently assessed all images qualitatively and quantitatively. The diagnostic performance was compared between G300 and G30.

Results: The G300 average qualitative score was higher than G30 (P < 0.001). G300 and G30 also differed quantitatively in the liver and mediastinum SUVmax, SD, and SNR (all P < 0.001), but had similar sensitivities (89.09% vs. 86.36%, P = 0.250). The G300 group had higher accuracy (79.73%) and a larger area under the curve (0.709) than G30 (77.70% and 0.695, respectively; all P > 0.05).

Conclusion: The 30-s total-body PET/CT could meet clinical diagnostic requirements for malignant tumors in patients intolerant to prolonged horizontal positioning.

Keywords: Diagnostic performance; Image quality; Lesion detectability; Total-body PET/CT; Ultrafast.

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References

    1. Krause BJ, Schwarzenböck S, Souvatzoglou M. FDG PET and PET/CT. Recent Results Cancer Res. 2013;187:351–69. - DOI
    1. Cherry SR, Jones T, Karp JS, Qi J, Moses WW, Badawi RD. Total-body PET: maximizing sensitivity to create new opportunities for clinical research and patient care. J Nucl Med. 2018;59:3–12. - DOI
    1. Zhang X, Zhou J, Cherry SR, Badawi RD, Qi J. Quantitative image reconstruction for total-body PET imaging using the 2-meter long EXPLORER scanner. Phys Med Biol. 2017;62:2465–85. - DOI
    1. Tan H, Gu Y, Yu H, et al. Total-body PET/CT: current applications and future perspectives. AJR Am J Roentgenol. 2020;215:325–37. - DOI
    1. Nardo L, Abdelhafez YG, Spencer BA, Badawi RD. Clinical implementation of total-body PET/CT at University of California. Davis PET Clin. 2021;16:1–7. - DOI

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