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. 2022;19(2):131-136.
doi: 10.2174/1567202619666220516124552.

Irregular Baseline Brain Activity in Coronary Artery Disease Patients with Cognitive Impairment: A Resting-state Functional Magnetic Resonance Imaging Study

Jingchen Zhang  1 , Jueyue Yan  1 , Jianhua Niu  1 , Zhipeng Xu  1 , Xing Fang  1 , Jingyu You  1 , Tong Li  1
Affiliations

Irregular Baseline Brain Activity in Coronary Artery Disease Patients with Cognitive Impairment: A Resting-state Functional Magnetic Resonance Imaging Study

Jingchen Zhang et al. Curr Neurovasc Res. 2022.

Abstract

Objective: Cognitive impairment has been suggested to be associated with coronary artery disease [CAD]; however, the underlying mechanism is not fully understood. Our current study aimed to explore the brain activity in CAD patients compared to healthy controls [HCs].

Methods: Twenty-two CAD patients and 23 HCs were enrolled in our study. A low-frequency oscillation at the voxel level in all participants based on the amplitude of low-frequency fluctuations [ALFF] was measured using resting-state functional magnetic resonance imaging. All participants underwent neuropsychological examinations [Mini-Mental State Examination, MMSE and Montreal Cognitive Assessment, MoCA] and visual acuity examination.

Results: CAD patients showed significantly lower ALFF values [P < 0.05] in the right precuneus gyrus [Precuneus_R], left supramarginal gyrus [Supramarginal_L], left angular gyrus [Angular_L], and left middle cingulum gyrus [Cingulum_Mid_L] than healthy controls. Lower MoCA scores in CAD patients significantly correlated with lower Supramarginal_L [P = 0.001] and Cingulate_ Mid_L [P = 0.004] ALFF values. Reduced visual acuity significantly correlated with lower Precuneus_R [P = 0.019] and Cingulate_Mid_L [P = 0.011] ALFF values in CAD patients.

Conclusion: These findings may provide further insight into the underlying neuropathophysiology of CAD with cognitive impairment.

Keywords: Coronary artery disease; cognition; functional magnetci resonance imaging; low-frequency fluctuations; minimental state examination; montreal cognitive assessment.

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Figures

Fig. (1)
Fig. (1)
Brain regions showing ALFF differences in CAD patients and healthy controls. CAD patients showed significantly lower ALFF values in the right precuneus gyrus [Precuneus_R], left supramarginal gyrus [Supramarginal_L], left angular gyrus [Angular_L], and left middle cingulum gyrus [Cingulum_Mid_L] compared to healthy controls.
See this image and copyright information in PMC

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