Conflicts of interest: P.M.B. received funding from the German Research Foundation, all outside the submitted work. L.H.L. reports consulting fees from Lexicon, Merck, Pharmacosmos, and Myokardia, lecture fees and consulting fees from Vifor, Bayer, Medscape, grant support, lecture fees, and consulting fees AstraZeneca, and Novartis, grant support and consulting fees from Relypsa and Boehringer Ingelheim, grant support from Boston Scientific, and lecture fees from Abbott, all outside the submitted work. A.J.S.C. reports personal fees from AstraZeneca, Bayer, Boehringer Ingelheim, Menarini, Novartis, Nutricia, Servier, Vifor, Abbott, Actimed, Arena, Cardiac Dimensions, Corvia, CVRx, Enopace, ESN Cleer, Faraday, Gore, Impulse Dynamics, and Respicardia, all outside the submitted work. G.S. reports no conflict of interest related to this work. Grants and personal fees from Vifor, grants and non-financial support and grants from Boehringer Ingelheim, personal fees from Societa´ Prodotti Antibiotici, grants and personal fees from AstraZeneca, personal fees from Roche, personal fees from Servier, grants from Novartis, personal fees from GENESIS, personal fees from Cytokinetics, personal fees from Medtronic, grants from Boston Scientific, grants from PHARMACOSMOS, all outside the submitted work.