Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul;32(4):604-610.
doi: 10.1111/jon.13004. Epub 2022 May 17.

Real-time assessment of individual optimal CT perfusion acquisition time in patients with ischemic stroke

Silvano Filice  1 , Antonio Pavarani  2 , Davide Cerasti  2
Affiliations

Real-time assessment of individual optimal CT perfusion acquisition time in patients with ischemic stroke

Silvano Filice et al. J Neuroimaging. 2022 Jul.

Abstract

Background and purpose: This study aims to investigate the feasibility of a "real-time" estimate of the optimal CT perfusion (CTP) acquisition time (Top ) in ischemic stroke patients.

Methods: The arterial input function, the venous output function (VOF), and the time-attenuation curves of ischemic core and ischemic penumbra of 51 patients with acute ischemic stroke in anterior circulation were obtained. The curves were analyzed to determine for each patient the Top value; additionally, several time parameters were derived from each waveform. The relationship between each of these parameters and Top was investigated.

Results: We found a strong linear correlation between each time parameter derived from VOF curve and Top , suggesting that the VOF waveform is rescaled from patient to patient without significant change in shape.

Conclusions: The linear correlation between Top and the VOF time to peak is well suited to implement a new technique to automatically customize the patient's CTP acquisition time. The method does not require an additional dose of contrast medium and does not increase the overall study time, so its use would be desirable to decrease the average radiation dose.

Keywords: CT perfusion; acquisition time; ischemic stroke; optimization.

PubMed Disclaimer

References

REFERENCES

    1. Campbell BC, Weir L, Desmond PM, et al. CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke. J Neurol Neurosurg Psychiatry 2013;84:613-18.
    1. Nogueira RG, Jadhav AP, Haussen DC, et al. DAWN trial investigators. thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med 2018;378:11-21.
    1. Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 2018;378:708-18.
    1. Ma H, Campbell BCV, Parsons MW, et al. Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke. N Engl J Med 2019;380:1795-803.
    1. Wintermark M, Wade WS, Ko NU, et al. Dynamic perfusion CT: optimizing the temporal resolution and contrast volume for calculation of perfusion CT parameters in stroke patients. AJNR Am J Neuroradiology 2004;25:720-29.

LinkOut - more resources