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Review
. 2022 Aug 1;48(8):862-865.
doi: 10.1097/DSS.0000000000003487. Epub 2022 May 17.

Update on Exosomes in Aesthetics

Nina Hartman  1 , Jameson Loyal, Sabrina Fabi
Affiliations
Review

Update on Exosomes in Aesthetics

Nina Hartman et al. Dermatol Surg. .

Abstract

Background: In dermatology, exosomes have been leveraged given their roles in wound healing, cell migration, extracellular matrix reconstruction, and angiogenesis.

Objective: The purpose of this article is to review the literature investigating the use of exosomes in skin rejuvenation and hair regeneration.

Materials and methods: The PubMed database was searched for studies published through October 2021.

Results: Early preclinical studies in aesthetics have demonstrated promising effects of exosomes on skin rejuvenation and hair growth in in vitro and murine models. Despite this, only 1 clinical study has been published to date, and there are no FDA-approved products on the market.

Conclusion: Variation in purification techniques and practical issues surrounding isolation, storage, scalability, and reproducibility of an exosome product represent ongoing hindrances to the movement of exosomes into the clinical sphere.

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References

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    1. Xiong M, Zhang Q, Hu W, Zhao C, et al. The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacol Res 2021;166:105490.

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