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Case Reports
. 2022 May 17;15(5):e245863.
doi: 10.1136/bcr-2021-245863.

Psilocybin-induced takotsubo cardiomyopathy

Wiktoria Julia Kotts  1 , David T Gamble  1 , Dana K Dawson  1 , David Connor  2
Affiliations
Case Reports

Psilocybin-induced takotsubo cardiomyopathy

Wiktoria Julia Kotts et al. BMJ Case Rep. .

Abstract

We present a case of takotsubo cardiomyopathy following recreational ingestion of Psilocybe semilanceata (known as 'magic mushrooms'). The patient presented with respiratory distress and pulmonary oedema responding to standard medical measures. Investigations included: echocardiogram, cardiac MRI and angiogram. Based on our search, we suggest this is only the second recognised case in the published literature.

Keywords: clinical diagnostic tests; drug misuse (including addiction); poisoning.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
(A) Initial ECG showing left bundle branch block and sinus tachycardia. (B) Repeat ECG taken several days following presentation, showing sinus rhythm with antero-lateral T-wave inversion and prolonged QT interval.
Figure 2
Figure 2
(A, B) Diagnostic coronary angiography at presentation without evidence of obstructive coronary lesions. (C) Echocardiogram in systole at presentation showing severe left ventricular systolic dysfunction and akinesia of the entire apex and akinesia of the mid-cavity septal and lateral walls. (D) T2-STIR sequence on cardiac MRI showing increased signal consistent with apical myocardial oedema.
See this image and copyright information in PMC

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