Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug;37(10):2614-2616.
doi: 10.1007/s11606-022-07652-9. Epub 2022 May 17.

Persistence and Waning of Natural SARS-CoV-2 Antibodies Over 18 Months: Long-Term Durability of IgG Humoral Response in Healthcare Workers

Jose F Varona  1   2 , Javier Muñiz  3   4 , Vanesa Balboa-Barreiro  5 , Francisco Peñalver  6 , Elena Abarca  7 , Cristina Almirall  7 , Jose María Castellano  8   3   9   10
Affiliations

Persistence and Waning of Natural SARS-CoV-2 Antibodies Over 18 Months: Long-Term Durability of IgG Humoral Response in Healthcare Workers

Jose F Varona et al. J Gen Intern Med. 2022 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they do not have a conflict of interest.

Figures

Figure 1
Figure 1
Evolution of anti-SARS-CoV-2 titers over time. Linear mixed model for the SARS-CoV-2 IgG antibodies decline, with the overall mean trajectory from the mean baseline level. The mean trajectory and 95% confidence interval are shown as a solid line and shaded gray area, respectively. The dashed vertical line represents the mean time to loss of antibodies from baseline and the dashed horizontal line represents the titer threshold of 1.1 A.U.
See this image and copyright information in PMC

References

    1. Hall VJ, Foulkes S, Charlett A, et al. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN) [published correction appears in Lancet. 2021 May 8;397(10286):1710]. Lancet. 2021;397(10283):1459-1469. 10.1016/S0140-6736(21)00675-9 - PMC - PubMed
    1. Varona JF, Madurga R, Peñalver F, et al. Kinetics of anti-SARS-CoV-2 antibodies over time. Results of 10 month follow up in over 300 seropositive health care workers. Eur J Intern Med. 2021;89:97–103. doi: 10.1016/j.ejim.2021.05.028. - DOI - PMC - PubMed
    1. Angel Y, Spitzer A, Henig O, et al. Association between vaccination with BNT162b2 and incidence of symptomatic and asymptomatic SARS-CoV-2 infections among health care workers. JAMA. 2021;325(24):2457–2465. doi: 10.1001/jama.2021.7152. - DOI - PMC - PubMed
    1. Vitale J, Mumoli N, Clerici P, De Paschale M, Evangelista I, Cei M, Mazzone A. Assessment of SARS-CoV-2 reinfection 1 year after primary infection in a population in Lombardy, Italy. JAMA Intern Med. 2021;181(10):1407–1408. doi: 10.1001/jamainternmed.2021.2959. - DOI - PMC - PubMed
    1. Israel A, Shenhar Y, Green I, et al. Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection. Vaccines (Basel) 2021;10(1):64. doi: 10.3390/vaccines10010064. - DOI - PMC - PubMed